4025-75-6

Basic information

• Product Name: (4-Nitrophenyl)methanesulfonyl chloride
• Synonyms: BENZENEMETHANESULFONYL CHLORIDE, 4-NITRO-;(4-NITROPHENYL)METHANESULFONYL CHLORIDE;1-(4-NITROBENZYLSULFONYL)CHLORIDE;(4-Nitrophenyl)methanesulfonyl;(4-Nitrophenyl)methylsulphonyl chloride, tech;4-Nitro-ɑ-toluenesulfonyl chloride, 97%;4-Nitro-^a-toluenesulfonyl chloride, 97%;4-Nitro-alpha-toluenesulfonyl chloride, 97%
• CAS NO: 4025-75-6
• Molecular Formula: C₇H₆ClNO₄S
• Molecular Weight: 235.64
• EINECS: 1308068-626-2
• Mol File: 4025-75-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 91-92°C
• Boiling Point: 396.4 °C at 760 mmHg
• Flash Point: 193.6 °C
• Appearance: /
• Density: 1.57g/cm3
• Vapor Pressure: 3.9E-06mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: (4-Nitrophenyl)methanesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Nitrophenyl)methanesulfonyl chloride(4025-75-6)
• EPA Substance Registry System: (4-Nitrophenyl)methanesulfonyl chloride(4025-75-6)

Safety Data

• Hazard Codes: C,Xn
• Statements: 14-29-34-22
• Safety Statements: 22-26-30-36/37/39-45
• RIDADR: UN3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 4025-75-6(Hazardous Substances Data)

Usage

Uses

4-Nitrobenzylsulfonyl Chloride is used for preparation of HIV-1 Tat protein via native chemical ligation between a peptide thioester and a peptide containing (mercapto)leucine at N-terminus followed by desulfurization.

InChI:InChI=1/C7H6ClNO4S/c8-14(12,13)5-6-1-3-7(4-2-6)9(10)11/h1-4H,5H2

Upstream product

• 36639-50-6 Sodium 4-nitrobenzylsulphonate 
• 10026-13-8 phosphorus pentachloride 
• 100-14-1 4-nitrobenzyl chloride 
• 64039-36-7 S-(4-nitrobenzyl)isothiourea hydrobromide 
• 100-87-8 Benzylsulfonic acid 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 170640-75-2 S-(4-nitrophenylmethyl)thioacetate 
• 64-17-5 ethanol 
• 4357-96-4 S-(4-nitro-benzyl)-isothiourea; hydrochloride 
• 7782-50-5 chlorine 
• 71-23-8 propan-1-ol 
• 56-23-5 tetrachloromethane 
• 39549-05-8 bis(4-nitrobenzyl)disulfide 
• 53992-33-9 (4-nitrophenyl)-methanesulfonic acid 

Downstream Products

• 53992-04-4 Phenyl-p-nitro-phenylmethan-sulfonat 
• 100-14-1 4-nitrobenzyl chloride 
• 874157-87-6 2-{methoxy-[1-(4-nitro-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester 
• 340041-91-0 1-(4-nitrophenylmethylsulfonyl)pyrrolidine 
• 1271760-35-0 p-nitrobenzylsulfonamidoquinoline 
• 1428848-30-9 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-((4-nitrophenyl)methylsulfonamido)acetoxy)-ethyl)pyridine 1-oxide 
• 803727-91-5 N,N-bis(2,4-dimethoxybenzyl)-1-(4-nitrophenyl)methanesulfonamide 
• 88918-72-3 4-nitrobenzenemethanesulphonamide 
• 736-31-2 trans-4,4'-dinitrostilbene 
• 85260-63-5 Trimethyl-[(E)-2-(4-nitro-phenyl)-vinyl]-silane 
• 10602-28-5 C₈H₈⁽²⁾HNO₅S 
• 56157-83-6 (4-Nitro-phenyl)-methanesulfonic acid 2,4-dinitro-phenyl ester 
• 85650-20-0 (4-Nitro-phenyl)-methanesulfonic acid 2-chloro-ethyl ester 
• 85952-29-0 (4-nitro-phenyl)-methanesulfonic acid methylamide 

Relevant articles and documents

Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγInverse Agonist for Treatment of Castration-Resistant Prostate Cancer

We report the design, optimization, and biological evaluation of nuclear receptor RORγinverse agonists as therapeutic agents for prostate cancer treatment. The most potent compound 27 (designated as XY101) exhibited cellular activity with an IC50/su

Preparation method of almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine

The invention discloses a preparation method of an almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine. The main steps comprise: 1) preparing a Vilsmeier reagent by using BTC andDMF, and carrying out a sulfonylation reaction on p-nitr

Clean and economic synthesis of alkanesulfonyl chlorides from S-alkyl isothiourea salts via bleach oxidative chlorosulfonation

A simple procedure for clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is disclosed. This procedure is environment- and worker-friendly with the advantages of readily accessible materials and reagents, simple and safe operations, easy purification without chromatography, and affords high yields of up to 99%.