366799-82-8

Basic information

• Product Name: N-benzyl-5-fluoroisatin
• Synonyms: N-benzyl-5-fluoroisatin
• CAS NO: 366799-82-8
• Molecular Weight: 255.248
• Mol File: 366799-82-8.mol
• Article Data: 39

Chemical Properties

• CAS DataBase Reference: N-benzyl-5-fluoroisatin(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-5-fluoroisatin(366799-82-8)
• EPA Substance Registry System: N-benzyl-5-fluoroisatin(366799-82-8)

Safety Data

• Hazardous Substances Data: 366799-82-8(Hazardous Substances Data)

Upstream product

• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 351-09-7 N-(4-fluorophenyl)-2-(hydroxyimino) acetamide 
• 371-40-4 4-fluoroaniline 
• 620-05-3 iodomethylbenzene 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 1165892-16-9 C₁₅H₁₁FN₂O₂ 
• 1246886-55-4 C₁₈H₁₄FNO₃ 
• 1259382-75-6 (R)-benzyl 2-(1-benzyl-5-fluoro-3-hydroxy-2-oxoindolin-3-yl)acrylate 
• 1337552-02-9 (2R,3S)-1'-benzyl-5'-fluoro-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione 
• 1335103-44-0 1-benzyl-5-fluoro-2-oxo-1,3-dihydro-2H-indol-3-yl benzoate 
• 1334814-28-6 (Z)-N'-(1-benzyl-5-fluoro-2-oxoindolin-3-ylidene)isonicotinohydrazide 
• 1310936-16-3 ethyl 2-(1-benzyl-5-fluoro-3-hydroxy-2-oxoindolin-3-yl)acetate 
• 1368627-04-6 2-(benzylamino)-5-fluorobenzoic acid 
• 1379685-45-6 1-benzyl-6-fluoroquinazolin-4(1H)-one 
• 1590380-20-3 1-ethyl 3-methyl 6-benzyl-9-fluoro-2-methyl-5-oxo-5,6-dihydropyrrolo[1,2-c]quinazoline-1,3-dicarboxylate 
• 1509929-41-2 (S)-3-allyl-1-benzyl-5-fluoro-3-hydroxyindolin-2-one 

Relevant articles and documents

A new asymmetric activation strategy for hydrazones as acyl anion equivalents in the bimetallic catalyzed carbonyl-ene reaction

A new asymmetric activation strategy for hydrazones as acyl anion equivalents is developed in the bimetallic catalyzed carbonyl-ene reaction of isatins and hydrazones. Under mild conditions, optically active functionalized 3-hydroxy-2-oxindoles were furnished in up to 98% yield with up to 97% enantioselectivity. In this process, formaldehydetert-butylhydrazone which is seldom employed in asymmetric carbonyl-ene reactions accelerated by a metallic catalyst can be activated well by a Br?nsted base. A possible catalytic cycle is proposed.

Direct catalytic synthesis of β-(C3)-substituted pyrroles: A complementary addition to the Paal-Knorr reaction

The synthesis of β-(C3)-functionalized pyrroles is a challenging task and requires a multistep protocol. An operationally simple direct catalytic synthesis of β-substituted pyrroles has been developed. This one-pot multicomponent method combined aqueous succinaldehyde as 1,4-dicarbonyl, primary amines, and isatins to access hydroxyl-oxindole β-tethered pyrroles. Direct synthesis of the β-substituted free NH-pyrrole is the central intensity of this work. DFT-calculations and preliminary mechanism investigation support the possible reaction pathway. This journal is

Palladium catalyzed divergent cycloadditions of vinylidenecyclopropane-diesters with methyleneindolinones enabled by zwitterionic π-propargyl palladium species

A palladium-catalyzed divergent synthesis of spirooxindoles fused with a five- or a six-membered ring by a cycloaddition reaction of vinylidenecyclopropane-diesters with methyleneindolinones was disclosed. This protocol features anin situgenerated unprecedented zwitterionic π-propargyl palladium species in cycloaddition reactions and a switchable process between (3+2) and (4+2) cycloadditions by changing the phosphine ligand.