36691-02-8

Basic information

• Product Name: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate
• Synonyms: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate
• CAS NO: 36691-02-8
• Molecular Weight: 323.392
• Mol File: 36691-02-8.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate(36691-02-8)
• EPA Substance Registry System: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate(36691-02-8)

Safety Data

• Hazardous Substances Data: 36691-02-8(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 36691-01-7 ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)acetate 
• 57960-76-6 ethyl 2-(4-(benzylamino)phenyl)acetate 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 100-39-0 benzyl bromide 
• 496-12-8 isoindoline 
• 943742-86-7 C₁₂H₁₅BrO₂ 

Downstream Products

• 63610-08-2 indobufen 

Relevant articles and documents

α-Angelica Lactone in a New Role: Facile Access to N-Aryl Tetrahydroisoquinolinones and Isoindolinones via Organocatalytic α-CH2 Oxygenation

A method for the direct oxidation of various N-aryl tetrahydroisoquinolines and isoindolines to the corresponding lactams using α-angelica lactone as a catalyst was developed. The utility of the method was further demonstrated by synthesis of indoprofen and indobufen.

A g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biologically valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this "green" methodology was further demonstrated by applying in bioactive and drug valued target syntheses.

method for preparing indobufen using micro flow reactor

The present invention relates to a method for producing indobufen using ethyl 2-(4-aminophenyl)acetate, which can be industrially purchased, as a starting material and a method for applying the same to a micro flow reactor. According to the present invention, by producing indobufen using a micro flow reactor, the yield and purity of the produced indobufen can be improved, and time spent for the overall production procedure can be reduced. Accordingly, harmful compounds used during the production procedure can be stably used.