57960-76-6

Basic information

• Product Name: ethyl 2-(4-(benzylamino)phenyl)acetate
• Synonyms: ethyl 2-(4-(benzylamino)phenyl)acetate
• CAS NO: 57960-76-6
• Molecular Weight: 269.343
• Mol File: 57960-76-6.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-(benzylamino)phenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-(benzylamino)phenyl)acetate(57960-76-6)
• EPA Substance Registry System: ethyl 2-(4-(benzylamino)phenyl)acetate(57960-76-6)

Safety Data

• Hazardous Substances Data: 57960-76-6(Hazardous Substances Data)

Upstream product

• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 100-46-9 benzylamine 
• 57960-72-2 (4-benzylidenamino-phenyl)-acetic acid ethyl ester 

Downstream Products

• 77440-19-8 4-fenilacetato d'etile 
• 77440-45-0 [4-(2-Methyl-5-oxo-morpholin-4-yl)-phenyl]-acetic acid 
• 77440-37-0 [4-(2-Methyl-5-oxo-morpholin-4-yl)-phenyl]-acetic acid ethyl ester 
• 77440-53-0 [4-(2-Methyl-5-oxo-morpholin-4-yl)-phenyl]-acetic acid pentachlorophenyl ester 
• 63610-08-2 indobufen 
• 36691-02-8 ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate 
• 36691-01-7 ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)acetate 
• 77440-17-6 4-fenilacetato d'etile 
• 39718-80-4 4-(benzylamino)phenylacetic acid 

Relevant articles and documents

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

Activation of the nuclear farnesoid X receptor (FXR) which acts as cellular bile acid sensor has been validated as therapeutic strategy to counter liver disorders such as non-alcoholic steatohepatitis by the clinical efficacy of obeticholic acid. FXR antagonism, in contrast, is less well studied and potent small molecule FXR antagonists are rare. Here we report the systematic optimization of a novel class of FXR antagonists towards low nanomolar potency. The most optimized compound antagonizes baseline and agonist induced FXR activity in a full length FXR reporter gene assay and represses intrinsic expression of FXR regulated genes in hepatoma cells. With this activity and a favorable toxicity-, stability- and selectivity-profile it appears suitable to further study FXR antagonism in vitro and in vivo.

Direct N-alkylation of aromatic amines using a microflow reactor: Enhancement of selectivity and reactivity

A simple and highly atom-economical method for the direct N-alkylation of aromatic amines by using a microflow reactor was developed to overcome the problem of over-alkylation. In the developed method, high-yield conversion (up to 100%) was achieved in a relatively short reaction time. The ratio of mono- to di-benzylated products (3.57:1) was higher than that achieved with batch reactions conducted in a 1 L scale flask (0.87:1). The structural features of the microflow reactor meant that short-chain alkyl halides could be converted into products with high reactivity and selectivity under superheating conditions, although their boiling point was much lower than the reaction temperature. This method was successfully applied to the synthesis of a range of secondary amines including an intermediate of indobufen synthesis.

Visible light-mediated oxidative decarboxylation of arylacetic acids into benzyl radicals: Addition to electron-deficient alkenes by using photoredox catalysts

Reactions of arylacetic acids bearing an amino group at the para-position in the benzene ring with alkenes in the presence of a catalytic amount of transition metal polypyridyl complexes as photocatalysts under visible light illumination proceed smoothly to give the corresponding benzylated products via oxidative decarboxylation in good to high yields.