367-46-4Relevant articles and documents
A Chiroptical Molecular Switch with Distinct Chiral and Photochromic Entities and Its Application in Optical Switching of a Cholesteric Liquid Crystal
Van Delden, Richard A.,Mecca, Tommaso,Rosini, Carlo,Feringa, Ben L.
, p. 61 - 70 (2004)
Two new structurally related photoswitches are described, in which azobenzene photochromism is combined with the chirality of a 2,2′-dihydroxy-1,1′-binaphthyl unit. In system 1 the chiral binaphthyl moiety is bridged by a methylene tether, locking the biaryl chirality while in system 2 the biaryl core is unbridged and has considerable conformational flexibility. Both compound are capable of inducing cholesteric liquid crystalline phases and proved to be good photoswitches both in solution and in a liquid crystalline matrix. Compound 2 is capable of completely reversing the liquid crystalline chirality which is unique for a chiroptical molecular switch where the switching unit and the chiral moiety are separate entities.
Synthesis of substituted 2,3-dihydro-1H-boroles by transmetalation of aluminacyclopent-2-enes with BF3 · Et2O
Khafizova,Khusainova,Tyumkina,Dzhemilev
, p. 761 - 766 (2012/11/07)
A procedure was developed for selective synthesis of 4,5-dialkyl-1-fluoro- 2, 3-dihydro-1H-boroles via transmetalation of the corresponding aluminacyclopent-2-enes with BF3 · Et2O. 4,5-Dialkyl-1-fluoro-2,3-dihydro-1H-boroles were isolated as complexes with BEtF2. 4-Alkyl-5-dimethylaminomethyl-1-fluoro-2,3- dihydro-1H-boroles were synthesized for the first time.
N- [6-AMINO-S- (PHENYL) PYRAZIN-2-YL] -ISOXAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NAV1.8 CHANNEL MODULATORS FOR THE TREATMENT OF PAIN
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Page/Page column 56-57, (2009/01/20)
The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
PYRIDINE DERIVATIVES
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Page/Page column 159, (2009/01/20)
The present invention relates to compounds of the formula (I): (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
Dehydrotriphenylenes for the generation of bent molecular ribbons
Meier, Herbert,Rose, Bernd
experimental part, p. 536 - 543 (2011/10/17)
The synthetic sequences 1→11 and 17→23a lead to highly reactive mono- and bisdienophiles whose cycloaddition processes with in situ generated isobenzofuran 13 were studied: 11 + 13 → 15 and 23a + 2×13 → 24a.
Experimental and theoretical characterization of FSi(OCH3)2(OCH2)-: A gas phase fluoride-siloxirane adduct
Morgon, Nelson H.,Argenton, Andre B.,Da Silva, Maria L. P.,Riveros, José M.
, p. 1708 - 1716 (2007/10/03)
The structural characteristics and reactivity of the gas-phase FSi(OCH3)2(OCH2)- ion were investigated by a combination of ab initio calculations and FT-ICR techniques. The theoretical calculations for different possible structures reveal that carbanion and alkoxide ion type structures lead to ring closure upon geometry optimization to yield two different cyclic fluoride-siloxirane structures. The FSi(OCH3)2(cyc-OCH2)- ions containing the elusive siloxirane ring are estimated to be extremely stable with respect to F- (69 kcal mol-1) dissociation in agreement with earlier calculations on simpler systems. Experimentally, this ion is formed as a minor product (7%) in the gas-phase ion/molecule reaction of F- with Si(OMe)4 and is observed to undergo readily fluoride transfer to the parent neutral. This strongly suggests an ion with a structure corresponding to a fluoride adduct of a siloxirane species. Reaction of FSi(OCH3)2(OCH2)- with BF3, hexafluorobenzene, and gas-phase acids more acidic than ethanol further suggests that this ion is capable of reacting as an alkoxide type nucleophile or base. This latter behavior has been associated with the possibility of ring opening of the siloxirane in the collision complex that mediates this ion/molecule reaction.
Organoboranes. 31. A simple preparation of boronic esters from organolithium reagents and selected trialkoxyboranes
Brown, Herbert C.,Cole, Thomas E.
, p. 1316 - 1319 (2008/10/08)
The reaction of methyllithium with trimethoxyborane at -78°C in ethyl ether yields a mixture of methylated boranes and their corresponding ate complexes. We have found that under the same conditions triisopropoxyborane reacts cleanly with methyllithium to form the lithium methyltriisopropoxyborate complex. Protonation of this complex with anhydrous hydrogen chloride quantitatively yields methyl diisopropoxyborane. This reaction of organolithium reagent with triisopropoxyborane appears to provide a general, valuable route to boronic esters. Other alkoxyboranes were examined for their selectivity for monomethylation by methyllithium. In addition to triisopropoxyborane, triisobutoxyborane and tri-sec-butoxyborane also give the methylboronic esters quantitatively. This development provides the first general preparation of boronic esters from organolithium reagents.
