7318-81-2

Basic information

• Product Name: Boronic acid, methyl-, dimethyl ester
• Synonyms: Boronic acid, methyl-, dimethyl ester
• CAS NO: 7318-81-2
• Molecular Formula: C₃H₉BO₂
• Molecular Weight: 0
• Mol File: 7318-81-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 0.779g/cm³
• Vapor Pressure: 3640mmHg at 25°C
• Refractive Index: 1.327
• CAS DataBase Reference: Boronic acid, methyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, methyl-, dimethyl ester(7318-81-2)
• EPA Substance Registry System: Boronic acid, methyl-, dimethyl ester(7318-81-2)

Safety Data

• Hazardous Substances Data: 7318-81-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C3H9BO2/c1-4(5-2)6-3/h1-3H3

Upstream product

• 367-46-4 fluorodimethoxyborane 
• 917-54-4 methyllithium 
• 102-24-9 cyclotriboric acid trimethyl ester 
• 10294-34-5 boron trichloride 
• 121-43-7 Trimethyl borate 
• 823-96-1 Trimethylboroxine 
• 149-73-5 trimethyl orthoformate 
• 13061-96-6 dihydroxy-methyl-borane 
• 91083-26-0 (E)-1-hexenyldimethoxyborane 
• 868-81-5 chlorodimethoxyborane 

Downstream Products

• 593-90-8 trimethylborane 
• 4443-43-0 methoxy-dimethyl-borane 
• 5314-85-2 2,4,6-Trimethyl-[1,3,5,2,4,6]triazatriborinane 
• 7397-46-8 diethyl methoxy borane 
• 67-56-1 methanol 
• 112022-83-0 (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole 
• 4214-80-6 5-chloro-2-(methylamino)pyridine 

Relevant articles and documents

Process for the preparation of 1,3,2-oxazaborolidine compounds

A process is used for the preparation of 1,3,2-oxazaborolidine compounds. This process prepares compounds of formula (I) or (IA): in which: R1 is an alkyl or an aryl; and R2, R3, R4 and R5 are especially a hydrogen atom or an alkyl, wherein the following are reacted in two steps: a) a boric precursor compound with an acetal compound to give a boronate compound; and b) the boronate compound with an amino alcohol compound. This process avoids by-products and exhibits a very good stereospecificity.

Organoboranes. 31. A simple preparation of boronic esters from organolithium reagents and selected trialkoxyboranes

The reaction of methyllithium with trimethoxyborane at -78°C in ethyl ether yields a mixture of methylated boranes and their corresponding ate complexes. We have found that under the same conditions triisopropoxyborane reacts cleanly with methyllithium to form the lithium methyltriisopropoxyborate complex. Protonation of this complex with anhydrous hydrogen chloride quantitatively yields methyl diisopropoxyborane. This reaction of organolithium reagent with triisopropoxyborane appears to provide a general, valuable route to boronic esters. Other alkoxyboranes were examined for their selectivity for monomethylation by methyllithium. In addition to triisopropoxyborane, triisobutoxyborane and tri-sec-butoxyborane also give the methylboronic esters quantitatively. This development provides the first general preparation of boronic esters from organolithium reagents.