36710-53-9Relevant academic research and scientific papers
Modular Synthesis of Polysubstituted Quinolin-3-amines by Oxidative Cyclization of 2-(2-Isocyanophenyl)acetonitriles with Organoboron Reagents
Wang, Shihui,Xu, Jian,Song, Qiuling
, p. 6789 - 6794 (2021/09/02)
Polysubstituted quinolin-3-amines are vital structural motifs because of their broad biological activities as well as versatile transformational abilities. However, they are not easily accessible. We disclose a protocol with Mn(III) acetate as a mild one-
Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of quinolin-3-amines
Cai, Xian-Feng,Guo, Ran-Ning,Feng, Guang-Shou,Wu, Bo,Zhou, Yong-Gui
supporting information, p. 2680 - 2683 (2014/06/09)
A chiral phosphoric acid catalyzed asymmetric transfer hydrogenation of aromatic amines, quinolin-3-amines, was successfully developed with up to 99% ee. To supplement our previous work on the Ir-catalyzed asymmetric hydrogenation of 2-alkyl substituted q
Synthesis of chiral exocyclic amines by asymmetric hydrogenation of aromatic quinolin-3-amines
Cai, Xian-Feng,Guo, Ran-Ning,Chen, Mu-Wang,Shi, Lei,Zhou, Yong-Gui
supporting information, p. 7245 - 7248 (2014/06/23)
Asymmetric hydrogenation of aromatic quinolin-3-amines was successfully developed with up to 94% enantiomeric excess (ee). Introduction of the phthaloyl moiety to the amino group is crucial to eliminate the inhibition effect caused by the substrate and pr
Palladium-catalyzed asymmetric hydrogenation of 3-phthalimido substituted quinolines
Cai, Xian-Feng,Huang, Wen-Xue,Chen, Zhang-Pei,Zhou, Yong-Gui
supporting information, p. 9588 - 9590 (2014/08/18)
Homogeneous Pd-catalyzed asymmetric hydrogenation of 3-phthalimido substituted quinolines was successfully developed, providing facile access to chiral substituted tetrahydroquinolines bearing two contiguous stereogenic centers with up to 90% ee. This jou
3-Pyridylnitrene, 2- and 4-pyrimidinylcarbenes, 3-quinolylnitrenes, and 4-quinazolinylcarbenes. Interconversion, ring expansion to diazacycloheptatetraenes, ring opening to nitrile ylides, and ring contraction to cyanopyrroles and cyanoindoles
Wentrup, Curt,Lan, Nguyen Mong,Lukosch, Adelheid,Bednarek, Pawel,Kvaskoff, David
, p. 743 - 753 (2013/06/27)
Precursors of 3-pyridylnitrene and 2- and 4-pyrimidinylcarbenes all afford mixtures of 2- and 3-cyanopyrroles on flash vacuum thermolysis, but 3-cyanopyrroles are the first-formed products. 3-Quinolylnitrenes and 4-quinazolinylcarbenes similarly afford 3-cyanoindoles. 2-Pyrimidinylcarbenes rearrange to 3-pyridylnitrenes, but 4-pyrimidinylcarbenes and 4-quinazolinylcarbenes do not necessarily rearrange to the corresponding 3-pyridylnitrenes or 3-quinolylnitrenes. The ring contraction reactions are interpreted in terms of ring opening of either the nitrenes or the diazacycloheptatetraenes to nitrile ylides.
First synthesis of benzopyridoiodolium salts and twofold Buchwald-Hartwig amination for the total synthesis of quindoline
Letessier, Julien,Detert, Heiner
experimental part, p. 290 - 296 (2012/04/17)
The first synthesis of cyclic benzopyridoiodolium salts is described. These hypervalent iodine intermediates are used in an efficient strategy for the construction of the -carboline core. This novel approach involves a twofold palladium-catalyzed Buchwald
A facile one-pot synthesis of 2-substituted-3-aminoquinolines: Preparation of benzo[b]naphthyridine-3-carbonitriles
Wang, Yanong D.,Boschelli, Diane H.,Johnson, Steven,Honores, Erick
, p. 2937 - 2942 (2007/10/03)
A facile one-pot synthesis of 3-aminoquinolines from ortho- aminobenzaldehydes was developed. Ethyl 6,7-dimethoxy-3-aminoquinoline-2- carboxylate, a key intermediate for the preparation of a 4-anilino-benzo[b][1,5] -naphthyridine-3-carbonitrile, was efficiently prepared by this method. Synthetic routes to 4-anilino-benzo[b][1,5]-naphthyridine-3-carbonitrile and 4-anilino-benzo[b][1,8]-naphthyridine-3-carbonitrile are described.
