36719-40-1

Usage

Uses

Used in Organic Synthesis:
(1E)-1-phenyl-3,3-di(propan-2-yl)triaz-1-ene is used as a building block for the synthesis of more complex organic compounds. Its unique structure and functional groups make it a versatile component in the creation of various organic molecules.
Used in Pharmaceutical Research:
(1E)-1-phenyl-3,3-di(propan-2-yl)triaz-1-ene is used as a starting material or intermediate in the development of new pharmaceuticals. Its triazole core and substituents may contribute to the compound's biological activity, making it a candidate for further exploration in drug discovery.
Used in Chemical Research:
(1E)-1-phenyl-3,3-di(propan-2-yl)triaz-1-ene is used as a research tool to study the properties and reactivity of triazole-containing compounds. Its synthesis and reactions can provide insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge.

Upstream product

• 108-18-9 diisopropylamine 
• 62-53-3 aniline 
• 4111-54-0 lithium diisopropyl amide 
• 100-59-4 phenylmagnesium chloride 
• 100-34-5 benzene diazonium chloride 

Downstream Products

• 3597-91-9 biphenyl-4-yl methanol 
• 90-41-5 2-phenylaniline 
• 92-67-1 4-phenylalanine 
• 934-56-5 trimethyl(phenyl)stannane 
• 40885-33-4 ethyl 2,3-dioxo-3-phenylpropanoate 2-phenylhydrazone 
• 4792-53-4 α-Methyl-α-phenylazo-acetessigsaeure-ethylester 
• 35458-22-1 1-phenyl-2-(2-phenylhydrazono)-2-(phenylsulfonyl)ethanone 

Relevant academic research and scientific papers

Synthesis of Aryl Trimethylstannane via BF3·OEt2-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature

BF3·OEt2-mediated cross-coupling of (SnMe3)2 with aryl triazene offers a new strategy for the synthesis of aryl stannane. A variety of synthetically useful aryl trimethylstannanes were produced in moderate to good yields with this metal-free approach. One-pot sequential Stille cross-coupling with different aryl bromides provides a short entry to both symmetrical and unsymmetrical biaryl compounds.

PREPARATION AND MEDICAL USE OF TRIAZENES

The present invention relates to a novel method for preparing triazenes. Further, the invention relates to novel triazenes and the use of N2O for preparing a compound comprising a triazene group. Further, the invention relates to the use of the

Synthesis of triazenes with nitrous oxide

Triazenes are valuable compounds in organic chemistry and numerous applications have been reported. Furthermore, triazenes have been investigated extensively as potential antitumor drugs. Here, we describe a new method for the synthesis of triazenes. The procedure involves a reagent which is rarely used in synthetic organic chemistry: nitrous oxide (N2O, laughing gas ). Nitrous oxide mediates the coupling of lithium amides and organomagnesium compounds while serving as a nitrogen donor. Despite the very inert character of nitrous oxide, the reactions can be performed in solution under mild conditions. A key advantage of the new procedure is the ability to access triazenes with alkynyl and alkenyl substituents. These compounds are difficult to prepare by conventional methods because the required starting materials are unstable. Some of the new alkynyltriazenes were found to display high cytotoxicity in in vitro tests on ovarian and breast cancer cell lines.

KINETICS AND MECHANISM OF ACID CATALYZED DECOMPOSITION OF 1-PHENYL-3,3-DIALKYLTRIAZENES

Five model 1-phenyl-3,3-dialkyltriazenes (methyl, ethyl, 2-propyl, butyl, cyclohexyl) have been synthesized and their acid-catalyzed decomposition kinetics have been investigated spetrophotometrically in aqueous ethanol (40 vol.percent) with pivalic acid as the catalyst.The results show that the rate-determining step is catalyzed by the proton.The decrease in the observed rate constant at higher concentrations of pivalic acid is explained by the formation of an unreactive complex of the nondissociated acid and respective triazene.The steric effect of alkyl groups on the catalytic rat constants is discussed.