3672-39-7

Usage

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 5599, 1983 DOI: 10.1016/S0040-4039(00)94151-0

InChI:InChI=1/C14H10N2O/c17-10-12-14(11-6-2-1-3-7-11)15-13-8-4-5-9-16(12)13/h1-10H

Upstream product

• 89021-05-6 pyridin-3-yl)methyl>phosphonsaeure-diisopropylester 
• 504-29-0 2-aminopyridine 
• 70508-79-1 (E)-3-Oxo-3-phenyl-1-propenyl-phosphonsaeure-diisopropylester 
• 84542-96-1 trans-1,2-Epoxy-3-oxo-3-phenylprop-1-ylphosphonsaeurediisopropylester 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 292638-85-8 acrylic acid methyl ester 
• 1883-96-1 N-benzylidenepyridin-2-amine 
• 1314079-01-0 N-(1-phenylallyl)-2-aminopyridine 
• 100-52-7 benzaldehyde 
• 67-68-5 dimethyl sulfoxide 
• 104-55-2 3-phenyl-propenal 
• 14371-10-9 (E)-3-phenylpropenal 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 75-91-2 tert.-butylhydroperoxide 

Downstream Products

• 119448-82-7 ethyl 2-phenylimidazo[1,2-a] pyridine-3-carboxylate 
• 723341-56-8 4-[(E)-2-(2-phenylimidazo[1,2-a]pyridin-3-yl)vinyl]pyrimidin-2-amine 
• 159679-68-2 (2-phenyl-1H-imidazo[1,2-a]pyridin-3-yl)methanol 
• 1417910-23-6 3-(azidomethyl)-2-phenyl-1H-imidazo[1,2-a]pyridine 
• 1417910-32-7 2-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 1417910-33-8 2-phenyl-3-((4-p-tolyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

Inhibitive effect of imidazopyridine derivative towards corrosion of C38 steel in hydrochloric acid solution

The effect of adding 2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde derivative named (P2), newly synthesized on the electrochemical behavior of C38 steel in molar hydrochloric acid was investigated by using the weight-loss method, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS) measurements. EIS results show that the transfer resistance increases with the increase of concentration of P2 and it also had an inhibiting effect on C38 steel corrosion in HCl solutions. Weight-loss essays confirm that the corrosion rate decreases as the P2 concentration increases. The inhibition efficiency for this compound studied increased with the increase in the inhibitor concentrations to attain 91.7 % at the 10-3 M of P2. The potentiodynamic polarization curves indicated that P2 acted as a mixed-type inhibitor in hydrochloric acid.

Gluconic acid promoted cascade reactions of 2-phenylimidazo[1,2-a] pyridine-3-carbaldehyde with cyclohexane-1,3-dione to create novel fused bisheterocycles

Here in, we described the synthesis of novel bisheterocycles imidazopyridine bearing xanthenedione by reacting various substituted 2-phenylimidazo [1,2-a] pyridine-3-carbaldehyde with cyclohexane-1,3-dione in gluconic acid aqueous solution (GAAS) via a ta

H2O2/DMSO-Promoted Regioselective Synthesis of 3,3′-Bisimidazopyridinylmethanes via Intermolecular Oxidative C(sp2)-H Bond Activation of Imidazoheterocycles

In the past decade, metal-free approaches for C-C bond formation have attracted a great deal of attention due to their ease of use and low cost. This report represents a novel and metal-free synthesis of 3,3′-bisimidazopyridinylmethanes via intermolecular

Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Aim: To synthesize and evaluate the fused heterocyclic imidazo[1,2-a]pyridine based oxime as a reactivator against paraoxon inhibited acetylcholinesterase. Background: Organophosphorus compounds (OPs) include parathion, malathion, chlorpyrifos, monocrotop

Palladium(ii) catalyzed site-selective C-H olefination of imidazo[1,2-: A] pyridines

Herein, we disclose an efficient Pd(ii)-catalyzed site selective C8 alkenylation of imidazo[1,2-a]pyridines with electronically biased olefinic substrates. Notably, besides the presence of four C-H sites available, selective mono-alkenylation was achieved

Metal-free oxidative decarbonylative halogenation of fused imidazoles

An efficient strategy has been developed for the deformylative halogenation of carbaldehyde imidazo-fused heterocycles in the presence of TBHP controlled by temperature. A convenient and sequential functionalization (C8 to C3) portrays the synthetic utility of the current method.N-Heterocycle benzamide products were also observedviathe ring opening of imidazopyridines through the cleavage of C-C bond at high temperatures. Features of this method include temperature-controlled excellent regioselectivity, mild conditions and functional group tolerance.

Design, one-pot green synthesis and antimicrobial evaluation of novel imidazopyridine bearing pyran bis-heterocycles

Herein, we report design, one pot synthesis and antibacterial evaluation of novel imidazopyridine bearing pyran bis-heterocycles. The compounds were synthesized in an aqueous solution of gluconic acid under both conventional heating and ultrasound irradiation. The target compounds were obtained in good to moderate yields with yield of 65–88% in 20–60 min under ultrasonic irradiation. The compounds were characterized by spectroscopic methods IR, 1H NMR, 13C NMR, MS and HRMS. X-ray single crystal structure of 7i was also determined. The compounds were evaluated for antibacterial activity by measuring zone of inhibition using disk diffusion method that revealed that some compounds were inhibiting the growth of Gram +ve and Gram -ve bacteria. Result of minimum inhibitory concentration (MIC) showed that 7a, 7h & 7k from a series 7a-7k inhibited the growth of S. aureus. The minimum bactericidal concentration (MBC) value was determined for 7a, 7h & 7k. MBC/MIC ratio of the derivatives 7a, 7k & 7h suggest former two derivatives act as bactericidal agent & later act as bacteriostatic agents against Gram +ve bacteria. Haemolysis results showed that compounds are non-cytotoxic to erythrocytes.

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is

I2O5-Mediated Iodocyclization Cascade of N-(1-Arylallyl)pyridine-2-amines with Concomitant C=C Bond Cleavage: A Synthesis of 3-Iodoimidazo[1,2- a]pyridines

A facile method for the synthesis of 3-iodoimidazo[1,2-a]pyridines has been successfully developed involving an I2O5-mediated iodocyclization cascade of N-(1-arylallyl)pyridin-2-amines with concomitant C=C bond cleavage. Preliminary mechanistic studies reveal that this protocol might undergo an oxidative cyclization/decarboxylation/iodination sequence in which I2O5 is used as both an oxidant and an iodine source. The present protocol has advantages of wide substrate scope, simple operation, and metal-free conditions.

Method for synthesizing formyl-substituted imidazo[1,2a]pyridine compounds

The invention discloses a method for synthesizing formyl-substituted imidazo[1,2a]pyridine compounds. The method is carried out according to the following steps: taking a substituted pyridine allyl amine compound represented by the formula I as an initiat