36755-40-5Relevant academic research and scientific papers
A diversity-oriented approach to 1H-pyrazole-4,5-diols, 4-hydroxy-3H-pyrazol-3-ones, and phenylhydrazones from key intermediate 4-acetyloxy-3H-pyrazol-3-one
Masumoto, Eiichi,Okabe, Fumi,Fujioka, Toshihiro,Yamagata, Kenji,Maruoka, Hiroshi
, p. 2572 - 2587 (2014)
An approach to 1H-pyrazole-4,5-diols 4a-d, 4-hydroxy-3H-pyrazol-3-ones 5a-d, and phenylhydrazones 6a-d from key intermediate 4-acetyloxy-3Hpyrazol-3-one 3a is described. 4-Alkylidene-3H-pyrazol-3-ones 1a-c were reacted with m-chloroperbenzoic acid in the
Diastereodivergent and enantioselective access to spiroepoxides via organocatalytic epoxidation of unsaturated pyrazolones
Meninno, Sara,Roselli, Angelo,Capobianco, Amedeo,Overgaard, Jacob,Lattanzi, Alessandra
supporting information, p. 5030 - 5033 (2017/11/06)
Readily available chiral amine-thioureas are effective catalysts for the first diastereo- and enantioselective epoxidation of unsaturated pyrazolones. The trans- or cis-spiroepoxides are preferentially obtained in good yield and high to excellent enantios
Synthesis and DNA cleavage activity of functionalized pyrazol-3-ones containing oxime ester
Masumoto, Eiichi,Kashige, Nobuhiro,Okabe, Fumi,Miake, Fumio,Yamagata, Kenji,Maruoka, Hiroshi
, p. 1293 - 1306 (2016/07/26)
A facile access to the synthesis of functionalized pyrazol-3-ones containing oxime ester from 4-hydroxypyrazol-3-ones, which were prepared starting from 4- Alkylidenepyrazol-3-one, in moderate to good yields is reported. The structures of all products wer
A New Synthesis of 4,5-Dihydroxy-pyrazoles
Kirschke, Klaus,Schmitz, Ernst
, p. 35 - 44 (2007/10/02)
1-Aryl-pyrazolin-5-ones 1 are converted by Knoevenagel condensation with acetone or by reaction with 2,2-dimethyl-1,3-dioxolane 6 to 1-aryl-4-isopropyliden-pyrazolin-5-ones 2.The compounds 2 are epoxidized by hydrogen peroxide forming the spiro-epoxides 3, which can be cleaved to 4,5-dihydroxy-pyrazoles 4 under acidic conditions. 4-Acetoxy-5-hydroxy-pyrazoles 13 are formed directly, when 3 are cleaved in presence of acetic anhydride.The 3,3',3'-trimethyl-1-(4-nitro-phenyl)-pyrazolin-4-spiro-2'-oxiran-5-one 3b undergoes rearrangement to the 1,3-dioxolopyrazole 12.
Oxopyrazoline-spiro-oxirans. A New Class of Reactive Heterocycles
Ege, Seyhan N.,Adams, Alan. D.,Gess, E. Joseph,Ragone, Katherine S.,Kober, Brian J.,et al.
, p. 325 - 332 (2007/10/02)
Chemical and spectral properties of a series of 1-oxa-5,6-diazaspirohept-6-en-4-ones, synthesized by the oxidation of 4-alkylidene- or 4-arylidene-1-aryl-2-pyrazolin-5-ones are reported
