13292-56-3

Basic information

• Product Name: 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE
• Synonyms: 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE;5-METHYL-2-PHENYL-3-PYRZOLIDINONE;5-Methyl-2-phenylpyrazolidin-3-one
• CAS NO: 13292-56-3
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Mol File: 13292-56-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 269.9°Cat760mmHg
• Flash Point: 117°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 0.00707mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE(13292-56-3)
• EPA Substance Registry System: 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE(13292-56-3)

Safety Data

• Hazardous Substances Data: 13292-56-3(Hazardous Substances Data)

Usage

General Description

5-METHYL-2-PHENYL-3-PYRAZOLIDINONE, also known as Mo-Methyl-PZ, is an organic compound commonly used as a pharmaceutical intermediate, and as a starting material for the synthesis of various pharmaceutical products. It is a white to off-white crystalline powder that is soluble in organic solvents, and is commonly used in the production of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly in the synthesis of the drug phenylbutazone. It is also used as a reagent in organic synthesis and in the manufacturing of dyes and pigments. This chemical has a relatively low toxicity, but should be handled with care and in accordance with safety guidelines.

InChI:InChI=1/C10H12N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6,8,11H,7H2,1H3

Upstream product

• 3724-65-0 2-butenoic acid 
• 100-63-0 phenylhydrazine 
• 623-43-8 crotonic acid methyl ester 
• 89-25-8 edaravone 
• 503-64-0 (Z)-but-2-enoic acid 

Downstream Products

• 36755-40-5 2,2,7-trimethyl-5-phenyl-1-oxa-5,6-diazaspiro<2.4>hept-6-en-4-one 
• 1128-54-7 3-methyl-1-phenyl-1H-pyrazole 
• 74451-57-3 (E)-5,5'-dimethyl-2,2'-diphenyl-2H,2'H-[4,4']bipyrazolylidene-3,3'-dione 
• 89-25-8 edaravone 
• 1392402-92-4 C₂₇H₂₂ClFN₄O₃S 
• 1392402-83-3 C₂₇H₂₃ClN₄O₃S 
• 1392402-84-4 C₂₇H₂₂Cl₂N₄O₃S 
• 1392402-85-5 C₂₇H₂₂Cl₂N₄O₃S 
• 1392402-86-6 C₂₇H₂₂ClN₅O₅S 
• 1392402-87-7 C₂₈H₂₅ClN₄O₄S 
• 1392402-88-8 C₂₇H₂₃ClN₄O₄S 
• 1392402-89-9 C₂₇H₂₃ClN₄O₄S 
• 1392402-90-2 C₂₉H₂₅ClN₄O₃S 
• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 

Relevant articles and documents

Synthesis of pyrazolones and pyrazoles via Pd-catalyzed aerobic oxidative dehydrogenation

A palladium-catalyzed oxidative dehydrogenation reaction in the presence of AMS and base to synthesize pyrazolones and pyrazoles was identified. This method can be utilized to a wide range of substrates, operates under mild react conditions and can give high yields. We believe it could be used as an alternative protocol for the classical dehydrogenation reactions.

Bipyrazole derivative, and medicine or reagent comprising the same as active component

A medicine or reagent comprising a bipyrazole derivative of the following formula (I), wherein R1 and R2 are individually a hydrogen atom, aryl group, alkyl group having 1-5 carbon atoms, or alkoxycarbonylalkyl group having a total of 3-6 carbon atoms, R3 and R4 are individually a hydrogen atom, alkyl group having 1-5 carbon atoms, cycloalkyl group having 5-7 carbon atoms, hydroxyalkyl group having 1-3 carbon atoms, benzyl group, naphthyl group, or substituted or unsubstituted phenyl group, as an active component. The medicine is useful for effectively capturing active oxygen and free radicals which cause adult diseases such as cerebral ischemia, heart disease, digestive system disease, and carcinoma, as well as inflammation, and for diagnosing diseases associated with in vivo free radicals.