368-21-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzyloxy-2-fluoro-benzene is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure contributes to the development of new drugs, enhancing their efficacy and selectivity in treating different medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Benzyloxy-2-fluoro-benzene serves as an essential component in the production of pesticides and other crop protection agents. Its incorporation aids in improving the effectiveness of these products, ensuring better agricultural yields.
Used in Dye Production:
1-Benzyloxy-2-fluoro-benzene is utilized as a precursor in the manufacturing process of dyes. Its chemical properties allow for the creation of vibrant and stable colorants used in various industries, including textiles and printing.
Used in Perfume Industry:
1-BENZYLOXY-2-FLUORO-BENZENE is also employed in the perfume industry, where it contributes to the development of unique and long-lasting fragrances. Its aromatic properties make it a valuable ingredient in the formulation of high-quality perfumes.
Used in Specialty Chemicals:
1-Benzyloxy-2-fluoro-benzene finds applications in the production of specialty chemicals, which are used in a wide range of industries, such as plastics, coatings, and adhesives. Its versatility and reactivity make it a valuable component in these chemical formulations.

InChI:InChI=1/C13H11FO/c14-12-8-4-5-9-13(12)15-10-11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 100-51-6 benzyl alcohol 
• 190661-29-1 2-benzyloxyphenylboronic acid 
• 367-12-4 2-fluorophenol 
• 100-39-0 benzyl bromide 

Downstream Products

• 133057-82-6 1-benzyloxy-4-bromo-2-fluorobenzene 
• 850364-08-8 4-(benzyloxy)-1H-indazole 
• 351210-09-8 7-benzyloxyindazole 

Relevant academic research and scientific papers

Novel synthesis of desymmetrized resorcinol derivatives: Aryl fluoride displacement on deactivated substrates

A short, high-yielding synthesis of differentially substituted resorcinol derivatives has been developed that utilizes 1,3-difluorobenzene as the starting material and employs sequential nucleophilic aromatic substitution (S NAr) reactions to generate desymmetrized products. The scope and limitations of the second SNAr reaction on the deactivated 1-alkoxy-3-fluorobenzene intermediates have been investigated. This methodology has also been employed in the synthesis of desymmetrized catechol derivatives from 1,2-difluorobenzene.

List fluoro Radicamine compounds and their use and preparation method

The invention discloses a mono-fluorinated Radicamine compound which has a structure as shown in a formula (1), and further provides a preparation method for the mono-fluorinated Radicamine compound with the structure as shown in the formula (1) and an application of the mono-fluorinated Radicamine compound or the mono-fluorinated Radicamine compound prepared with the method to preparation of drugs for preventing and/or treating diabetes, drugs for preventing and/or treating Gaucher's diseases, drugs for preventing and/or treating tumors or antiviral drugs. The mono-fluorinated Radicamine compound provided by the invention is good in glycosidase inhibition activity.

Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition

Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. Fluorinated derivatives of radicamine A and B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies revealed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom.

Synthesis of aryl fluorides from potassium aryltrifluoroborates and selectfluor mediated by iron(III) chloride

The synthesis of fluorinated arenes by the iron-mediated fluorination of potassium aryltrifluoroborates with Selectfluor and potassium fluoride is described. The fluorination reaction uses commercially available reagents and without requiring the addition

Electrophilic fluorination of cationic Pt-aryl complexes

The electrophilic fluorination of several (triphos)Pt-aryl+ establishes the first example of aryl-F coupling from a Pt center.

Metal-free electrophilic fluorination of alkyl trifluoroborates and boronic acids

Secondary alkyl trifluoroborates undergo facile electrophilic fluorination under mild conditions to afford the corresponding benzylic fluorinated adducts in excellent yield.

Practical synthesis of aromatic ethers by SNAr of fluorobenzenes with alkoxides

Aromatic fluorines have been substituted by alkoxides in a variety of activated and unactivated aromatic systems.