36898-62-1

Upstream product

• 14688-37-0 cis-p,p'-dinitrostilbene oxide 
• 968-01-4 (2SR,3SR)-2,3-bis(4-nitrophenyl)oxirane 
• 57507-91-2 Acetic acid 1,2-bis-(4-nitro-phenyl)-2-oxo-ethyl ester 
• 57507-83-2 2-chloro-1,2-bis(4-nitrophenyl)ethanone 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 6067-45-4 4,4'-dinitrobenzil 
• 1158813-97-8 2-(4-methoxyphenyl)-4,5-bis(4-nitrophenyl)-1H-imidazole 
• 123371-45-9 ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 13295-04-0 1.2-bis(4-nitrophenyl)ethane-1,2-diol 
• 123351-51-9 3,4-dihydro-4-hydroxy-3-methyl-4,5-bis-(4-nitrophenyl)imidazole-2-thione 

Relevant academic research and scientific papers

Development of Imidazoline-2-one Derivatives as Potential Antifungal and Anthelminthic Agents: in silico and in vitro Evaluation

Based on appropriate values of synthetic accessibility concerning from ADMET properties and docking scores by docking against proteins 3OZU and 1OJ0, a series of 4,5-diphenyl-1H-imidazol-2-ones (I1?15) were synthesized. The key intermediate, 2-hydroxy-1,2-disubstitutedethanones (E1?15) were prepared by benzoin condensation using 2:1 ratio of aromatic aldehydes and thiamine in the presence of alkali. Further, these cyclized ethanones (E1?15) were treated with urea to yield 4,5-diphenyl-1H-imidazol-2-one derivatives (I1?15) and were characterized by IR,1H NMR, Mass spectra, and CHNO analysis. The synthesized compounds were screened for their anthelmintic potential on Pheretima Posthuma along with standard albendazole, and antifungal activity (minimum inhibitory concentration method) on Candida albicans and Aspergillus niger along with standard miconazole. The results revealed that among all the tested compounds I3, I4, and I7 show considerable synthetic accessibility, docking scores, anthelminthic, and antifungal activity.

Efficient Green Synthesis and Computational Chemical Study of Some Interesting Heterocyclic Derivatives as Insecticidal Agents

A series of 5,5-diarylhydantoin (Dilantin) 3, 4, and 7, imidazole 1, 2, 5, 6, 8, and 9, thiazole 10–12, triazinthione 13, 15, 16, and 17, and thiadiazine 14 derivatives, containing diverse hydrophobic groups, were green synthesized through one-pot stepwise reaction of aromatic aldehydes, vitamin B1, and nitrogen nucleophiles, for example, urea, thiourea, and thiosemicarbazide using grinding technique as well as conventional thermal methods. Such synthesized compounds have potent insecticidal activities; for example, compounds 4, 6, and 17 exhibited the highest insecticidal activity against both Plutella xylostella and Helicoverpa armigera with minimum inhibitory concentration values at 500?μg/mL and LD50 activities at 50?μg/mL. The density functional theory was then applied to explore the structural and electronic characteristics of these compounds. All the synthesized compounds have been characterized based on their elemental analyses and spectral data.

Preparation method and antineoplastic activity of novel ruthenium complex containing 4,4'-dibromo-2,2'-dipyridyl

The invention provides a preparation method and antineoplastic activity of a novel ruthenium complex containing 4,4'-dibromo-2,2'-dipyridyl. The preparation method is characterized by comprising the following steps that 1, 4-nitrobenzaldehyde and vitamin

A new protocol for one-pot synthesis of tetrasubstituted pyrroles using tungstate sulfuric acid as a reusable solid catalyst

A variety of tetrasubstituted pyrroles were synthesized in good yields in a one-pot, three-component reaction of α-hydroxyketones, malononitrile, and ammonium acetate using tungstate sulfuric acid (TSA) under solvent-free conditions.

Thiazolium salt immobilized on ionic liquid: An efficient catalyst and solvent for preparation of α-hydroxyketones

Aldehydes were efficiently converted to acyloins and benzoins using a new ionic liquid, 3-[2-(1-butyl-1H-imidazol-1,3-ium-3-yl)ethyl]-4,5-dimethyl-1,3- thiazol-3-ium dibromide 1. This ionic liquid is introduced as a catalyst and a solvent. Acyloins and benzoins were easily isolated from the reaction mixture via simple extraction, and the ionic liquid could be recycled for further use. Also, -hydroxy ketones with an aromatic and aliphatic substituent were prepared starting from aromatic and aliphatic aldehydes in the presence of ionic liquid 1.

Microwave assisted benzoin condensation using thiamine as catalyst

α-Hydroxyketones were prepared in appreciable yields at a very high speed, (by the benzoin condensation) under microwave irradiation using a catalytic amount of thiamine hydrochloride, from various aromatic as well as heteroaromatic aldehydes. They can be used as intermediates in NCE synthesis.

Mechanistic Studies in the Chemistry of Thiourea. Part 1. Reaction with Benzil Under Alkaline Conditions

Benzil reacts under alkaline conditions with 1,3-dimethylthiourea to form 4,5-dihydroxy-1,3-dimethyl-4,5-diphenyltetrahydroimidazole-2-thione (1); with 1-methylthiourea to form 3-methyl-5,5-diphenyl-2-thiohydantoin (9); and with thiourea to form both the corresponding hydantoin and 3a,7a-diphenyltetrahydroimidazoimidazole-2,5-dithione (19).The use of high field n. m. r. spectroscopy and benzil labelled with carbon-13 in the carbonyl group has permitted delineation of the reaction mechanisms and detection of a number of transient intermediates.

Application of Polymer-Bound Thiazolium Salts to the Synthesis of Acyloins and Benzoins: Effects of Solvent and Substituents of the Thiazolium Nucleus

Covalent immobilization of the thiazole nucleus on a chloromethylated polystyrene copolymer results in the formation of a catalytically active thiazolium salt, capable of repeated acyloin and benzoin condensations.The nature of the solvent and the substituents on the thiazolium nucleus has been found to have marked effects of the rate of catalysis.