123371-45-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 555-16-8 4-nitrobenzaldehdye 
• 57-13-6 urea 
• 4433-85-6 2-ethyl-3-oxobutanoic acid 
• 13295-04-0 1.2-bis(4-nitrophenyl)ethane-1,2-diol 
• 36898-62-1 4,4'-dinitrobenzoin 
• 619-73-8 4-nitrobenzyl chloride 
• 55718-51-9 1,1'-((4-nitrophenyl)methylene)diurea 
• 5315-87-7 4-nitrobenzaldehyde semicarbazone 
• 100-52-7 benzaldehyde 
• 674-82-8 4-methyleneoxetan-2-one 
• 64-17-5 ethanol 
• 205999-89-9 methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 898798-67-9 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester 

Downstream Products

• 1032631-03-0 C₁₂H₁₃N₅O₄ 
• 1427288-03-6 ethyl-4-(4-(9-(4-chlorophenyl)-1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-1,8-dioxoacridin-10(9H)-yl)phenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-05-8 ethyl-1,2,3,4-tetrahydro-4-(4-(1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-9-(4-nitrophenyl)-1,8-dioxoacridin-10(9H)-yl)phenyl)-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-06-9 ethyl-1,2,3,4-tetrahydro-4-(4-(1,2,3,4,5,6,7,8-octahydro-9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-1,8-dioxoacridin-10(9H)-yl)phenyl)-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-07-0 ethyl-1,2,3,4-tetrahydro-4-(4-(1,2,3,4,5,6,7,8-octahydro-9-(3,4-dimethoxyphenyl)-3,3,6,6-tetramethyl-1,8-dioxoacridin-10(9H)-yl)phenyl)-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-09-2 ethyl-4-(4-(9-(2,4-dichlorophenyl)-1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-1,8-dioxoacridin-10(9H)-yl)phenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-10-5 ethyl-4-(4-(9-(benzo[d][1,3]dioxol-6-yl)-1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-1,8-dioxoacridin-10(9H)-yl)phenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-11-6 ethyl-1,2,3,4-tetrahydro-4-(4-(1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-9-(4-cyanophenyl)-1,8-dioxoacridin-10(9H)-yl)phenyl)-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-12-7 ethyl-1,2,3,4-tetrahydro-4-(4-(1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-1,8-dioxo-9-phenylacridin-10(9H)-yl)phenyl)-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-13-8 ethyl-1,2,3,4-tetrahydro-4-(4-(1,2,3,4,5,6,7,8-octahydro-9-(3,4,5-trimethoxyphenyl)-3,3,6,6-tetramethyl-1,8-dioxoacridin-10(9H)-yl)phenyl)-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-14-9 ethyl-4-(4-(9-(4-bromophenyl)-1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-1,8-dioxoacridin-10(9H)-yl)phenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1427288-15-0 ethyl-1,2,3,4-tetrahydro-4-(4-(1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-9-(3-nitrophenyl)-1,8 dioxoacridin-10(9H)-yl)phenyl)-6-methyl-2-oxopyrimidine-5-carboxylate 

Relevant academic research and scientific papers

A simplified green chemistry approach to the Biginelli reaction using 'Grindstone Chemistry'

Solvent-free reactions that are complete in a few minutes. Grindstone Chemistry - a greatly evolved version of Toda's method of grinding solids together for solvent-free chemical reactions - has been described and its usefulness illustrated by the success

One-pot synthesis of dihydropyrimidinones using polyaniline-bismoclite complex. A facile and reusable catalyst for the biginelli reaction

Polyaniline-bismoclite complex was used as an efficient catalyst for the three-component condensation reaction of an aldehyde, β-ketoester, and urea in ethanol to afford the dihydropyrimidinones in excellent yields. Furthermore, after completion of reacti

Immobilized Cu(I) on organic-inorganic hybrid material: An effective and reusable catalyst for Biginelli reaction

The immobilized Cu(I) on organic-inorganic hybrid material was prepared and used as effective catalyst for the Biginelli reaction. In the presence of immobilized copper catalyst, aromatic aldehydes reacted with β-keto ester and urea (or thiourea) smoothly

Immobilized nickel(II) on organic-inorganic hybrid materials: The effective and reusable catalysts for Biginelli reaction

The immobilized nickel(II) on the organic-inorganic hybrid material was prepared and used as an effective catalyst for the Biginelli reaction. In the presence of the immobilized nickel catalyst, aromatic aldehydes reacted with ethyl acetoacetate and urea

Core–shell structured Fe3O4?SiO2-supported IL/[Mo6O19]: A novel and magnetically recoverable nanocatalyst for the preparation of biologically active dihydropyrimidinones

The synthesis and catalytic application of a novel magnetic silica-nanomaterial-supported ionic liquid/hexamolybdate (Fe3O4?SiO2-IL/[Mo6O19]) are reported. The Fe3O4?SiO2/s

Novel catalytic application of Ni@ZnO nanoparticles and ZnO nanoflakes in aqueous solution of NaPTS hydrotrope at room temperature via a green synthesis of 3,4-dihydropyrimidin-2(1H)-ones

We investigated a novel catalytic application of nickel-doped zinc oxide (Ni-ZnO) nanoparticles and zinc oxide (ZnO) nanoflakes at room temperature in an aqueous hydrotropic solution for the synthesis of biologically active dihydropyrimidones (DHPMs). Ni-

Synthesis, characterization and catalytic application of a novel polyethylene-supported Fe/ionic liquid complex

A novel polyethylene-supported Fe/ionic liquid complex (PEt@Fe/IL) is prepared, characterized and its catalytic performance is investigated in the synthesis of 3,4-dihydropyrimidinones. The chemical properties and thermal stability of the PEt@Fe/IL materi

A nanocrystalline CdS thin film as a heterogeneous, recyclable catalyst for effective synthesis of dihydropyrimidinones and a new class of carbazolyl dihydropyrimidinones: Via an improved Biginelli protocol

This is the first report on the use of a nanocrystalline cadmium sulphide (CdS) thin film coated glass reactor as an efficient tool for the synthesis of dihydropyrimidinones via multicomponent reactions of aldehydes, a β-ketoester, and urea/thiourea in et

Pentafluorophenylammonium triflate: An efficient, practical, and cost-effective organocatalyst for the Biginelli reaction

Asimple, inexpensive, environmentally friendly, and efficient route for the synthesis of 3,4-dihydropyrimidin- 2(1H)-one derivatives via the one-pot three-component Biginelli reaction using pentafluorophenylammonium triflate (PFPAT) as a catalyst is descr

One-pot synthesis of dihydropyrimidinones catalysed by lithium bromide: An improved procedure for the Biginelli reaction

LiBr catalyses efficiently the three component condensation reaction of an aldehyde, a β-ketoester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yield.