36926-17-7

Upstream product

• 3420-41-5 2-Phenyl-5,6-dihydro-4H-[1,3]oxazine 
• 98-88-4 benzoyl chloride 
• 129348-90-9 3-benzoylaminopropyl acetate 
• 13609-09-1 N-(3-hydroxypropyl)benzamide 
• 156-87-6 propan-1-ol-3-amine 
• 100-52-7 benzaldehyde 

Downstream Products

• 96160-08-6 3-methyl-2-phenyl-5,6-dihydro-4H-[1,3]thiazinium; iodide 
• 6638-35-3 2-phenyl-5,6-dihydro-4H-1,3-thiazine 

Relevant academic research and scientific papers

Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines

An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.

Synthesis of oxazines and thiazines by cyclodehydration of hydroxy amides and thioamides

Dihydro-1,3-oxazines and -thiazines were obtained by cyclodehydration of hydroxy amides and thioamides with PEG-linked Burgess reagent or under Mitsunobu conditions. Yields were generally higher with polymer-Burgess reagent, but both conditions failed to

Research on radioprotective agents: Δ-2 Thiazolines and homologous derivatives

Compounds derived from Δ-2 thiazoline, Δ-2 thiazolinium iodoalkylate and 4,5-dihydro-1,3 thiazine have been prepared and evaluated as potential antiradiation agents in mice. They generally have a low toxicity and significant radioprotective activity.