36937-71-0Relevant academic research and scientific papers
Design, synthesis, antibacterial, and antifungal studies of novel 3-substituted coumarinyl-triazine derivatives
Modh, Rahul P.,Patel, Amit C.,Chikhalia, Kishor H.
, p. 343 - 349 (2013)
A series of novel 3-substituted coumarinyltriazine derivatives were designed and synthesized from 3-carboxycoumarins via consecutive Knoevenagel and Pinner reactions in water. All synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, MS, and elemental analysis. Further, in vitro screening was carried out against four bacterial strains ( Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Salmonella typhi ) and two fungal strains ( Aspergillus niger and Aspergillus clavatus ).
Indium-mediated one-pot synthesis of new 4-allyl-2-amino-4H-chromenes in water
Shanthi, Gnanamani,Perumal, Paramasivan T.
, p. 2791 - 2794 (2008)
A one-pot synthesis of new 4-allyl-2-amino-4H-chromene-3-carbonitriles was achieved in good yields by indium-mediated three-component reaction of salicylaldehyde and malononitrile with different allyl bromides in water. Georg Thieme Verlag Stuttgart.
One-pot four-component approach for the construction of dihydropyridines and dihydropyridinones using amines and activated alkynes
Kiruthika, Selvarangam E.,Perumal, Paramasivan T.
, p. 3758 - 3767 (2014)
An efficient greener approach for the one-pot four-component synthesis of dihydropyridines has been developed utilizing l-proline as a base catalyst under solvent-free conditions. This domino reaction involves Huisgen dipolar additions using amines and activated alkynes for the formation of novel dihydropyridines. The synthesized dihydropyridines were subjected to acid treatment which resulted in the selective formation of dihydropyridinones as a single diastereomer.
Regio- and diastereoselective synthesis of (E)-3-(2-aminochromen-4-yl)-6-aryl-substituted fulvenes
Koz, Gamze,?ahin, Onur,Co?kun, Necdet
, p. 945 - 951 (2016)
A practical base-catalyzed route was developed for the regio- and diastereoselective synthesis of (E)-3-aminochromene-6-aryl-disubstituted fulvenes in high yields up to 94% starting with the Michael addition of cyclopentadiene to 2-iminochromenes in the k
Convenient synthesis of substituted 2-(2-iminocoumarin-3-yl)-thieno[2,3-d] pyrimidin-4-ones
Shynkarenko, Pavlo E.,Vlasov, Sergiy V.,Kovalenko, Sergiy M.,Shishkina, Svitlana V.,Shishkin, Oleg V.,Chernykh, Valentin P.
, p. 800 - 806 (2010)
(Chemical Equation Presented) The interaction of both 2-iminocoumarin-3- carbonitriles and 2-iminocoumarin-3-carbothioamides with 2-aminothiophen-3- carboxamides lead to formation of 3-(4-oxo-3,4-dihydrothieno [2,3-d]pyrimidin-2-yl)-2-iminocoumarins in tw
An efficient multi-component synthesis of (2-amino-3-cyano-4H-chromen-4-yl) phosphonic acid diethyl ester
Gaikwad,Undale,Shaikh,Pore
, p. 865 - 868 (2011)
(2-Amino-3-cyano-4H-chromen-4-yl) phosphonic acid diethyl esters are prepared via a single-step multi-component reaction of structurally diverse salicylaldehydes with malononitrile and triethyl phosphite using a catalytic amount of potassium phosphate in ethanol at ambient temperature. Use of potassium phosphate as an inexpensive catalyst makes the protocol more economical. Mild reaction conditions, simple work-up procedure are the added advantages of the present method.
Michael addition of α-azido ketones on iminocoumarin derivatives: An efficient access to new functionalized azido chromenes
Babu, Thelagathoti Hari,Kamalraja, Jayabal,Muralidharan, Doraiswamy,Perumal, Paramasivan T.
, p. 4093 - 4096 (2011)
A facile one-pot synthesis of functionalized azido chromenes was achieved by Michael addition of α-azido ketones on iminocoumarin derivatives obtained from salicylaldehydes and malononitrile. Synthesized azido chromenes were successfully transformed into
Inorganic base catalyzed synthesis of (2-amino-3-cyano-4H-chromene-4-yl) phosphonate derivatives via multi-component reaction under mild and efficient conditions
Dai, Peng,Zha, Gaofeng,Lai, Xiaoyan,Liu, Wei,Gan, Qianwen,Shen, Yongcun
, p. 63420 - 63424 (2014)
Various (2-amino-3-cyano-4H-chromene-4-yl) phosphonate derivatives were synthesized in good to excellent yields by condensation of diverse substituted salicylaldehyde, malononitrile and diethyl phosphite or diphenyl phosphite using anhydrous lithium hydro
A room temperature one-pot Knoevenagel-Chan-Evans-Lam coupling reaction for synthesis of N-aryl-2-Iminocoumarins in bio-mass-derived green solvent 2-methylTHF
Mandal, Prashant S.,Vijay Kumar
, (2019)
An efficient approach for the synthesis of biologically interesting N-aryl-2-iminocoumarins by a copper-catalyzed one-pot procedure has been developed by the reaction of 2-hydroxybenzaldehydes, malononitrile and arylboronic acids using triethylamine as a base in a bio-mass-derived green solvent 2-MethylTHF at room temperature. This protocol allows access to several N-aryl-2-iminocoumarins in high yields in a relatively short period of time under mild reaction conditions. The procedure operates by a simple telescoped process wherein 2-imino-2H-chromene-3-carbonitriles are formed in situ by the reaction of 2-hydroxybenzaldehyde, malononitrile, and TEA. Further a subsequent one-pot reaction of imine with the arylboronic afforded the target compounds. To understand the reaction mechanism, MALDI-ESI studies were performed, which showed the in situ generated iminocoumarins to be in ligation cooper to form a copper-iminocoumarin complex thus facilitating the smooth formation of N-aryl-2-iminocoumarins in the reaction. Overall, this protocol is practically valuable, useful in organic synthesis, shows good functional group tolerance and provides access to a diverse array of N-aryl-2-iminocoumarins derivatives.
DBU-catalyzed synthesis of novel 2-Amino-3-nitrile-4H-chromenes
Koz, Gamze,Koz, ?mer
, p. 647 - 653 (2017)
A simple method via the base-catalyzed Michael addition of nitroalkanes to 2-iminochromenes was developed, which leads to the production of highly functionalized 2-Amino-3-nitrile-4H-chromenes in good yields.
