37029-36-0

Usage

Uses

Used in Pharmaceutical Industry:
(4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid hydrazine is used as a potential drug candidate due to its unique structural features and potential biological activity. Its quinazoline core and hydrazine group are important structural motifs in medicinal chemistry, and the presence of a sulfanyl group may enhance its reactivity and interactions with biological targets.
Used in Drug Synthesis:
(4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid hydrazine can be used as a building block for synthesizing other bioactive molecules. Its complex structure and functional groups make it a promising starting point for the development of new drugs with potential therapeutic applications.
Further research and testing would be needed to fully understand the properties and potential applications of (4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid hydrazine. Its unique structural features and potential reactivity make it an interesting compound for exploration in the field of medicinal chemistry.

Upstream product

• 28831-38-1 (4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)acetic acid ethyl ester 
• 106-49-0 p-toluidine 
• 134-20-3 2-carbomethoxyaniline 
• 37641-50-2 3-(4-methylphenyl)-2-thioxoquinazolin-4-one 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 37641-50-2 2-Mercapto-3-(4-methylphenyl)-3,4-dihydroquinazolin-4-one 
• 118-92-3 anthranilic acid 
• 43009-17-2 4-methylphenyl dithiocarbamic acid triethylammonium 
• 28831-25-6 (4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid methyl ester 

Downstream Products

• 497167-53-0 C₂₄H₁₉FN₄O₂S 
• 105491-23-4 C₂₄H₁₉ClN₄O₂S 
• 56671-07-9 (4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid (2-chloro-benzylidene)-hydrazide 
• 105491-25-6 C₂₄H₁₉N₅O₄S 
• 56671-16-0 (4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid benzylidenehydrazide 
• 56671-15-9 (4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)acetic acid (4-hydroxybenzylidene)-hydrazide 
• 105491-24-5 C₂₅H₂₂N₄O₃S 
• 497082-68-5 C₂₅H₂₂N₄O₄S 
• 497167-43-8 C₂₄H₁₉FN₄O₂S 
• 497167-93-8 C₂₅H₂₂N₄O₃S 
• 497082-76-5 C₂₄H₁₉N₅O₄S 
• 1547192-82-4 ethyl (2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)acetylhydrazinylidene)methylphenoxy)acetate 
• 1087-99-6 3-(4-methylphenyl)quinazoline-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

Synthesis of methyl [3-alkyl-2-(2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamido] alkanoate

A series of methyl [3-alkyl-2-(2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamido] alkanoate 10-13a-f has been developed on the basis of the N-chemoselective reaction of 3-substituted quinazoline-2,4-diones 3a-d with ethyl chloroacetate and azide coupling method with amino acid ester hydrochloride. The precursor quinazoline diones 3a-d chemoselective reactions were studied using DFT(B3LYP)/6-311G level of theory and were prepared by a new rearrangement method from the corresponding 2-(3-methyl-4-oxo-3,4- dihydroquinazolin-2-ylthio) acetohydrazide 6. {figure presented}.

Small molecule mimetics of an interferon-α receptor interacting domain

Small molecules that mimic IFN-α epitopes that interact with the cell surface receptor, IFNAR, would be useful therapeutics One such 8-amino acid region in IFN-α2, designated IRRP-1, was used to derive 11 chemical compounds that belong to 5 distinct chemotypes, containing the molecular features represented by the key residues Leu30, Arg33, and Asp35 in IRRP-1 Three of these compounds exhibited potential mimicry to IRRP-1 and, in cell based assays, as predicted, effectively inhibited IFNAR activation by IFN-α Of these, compound 3 did not display cell toxicity and reduced IFN-α- inducible STAT1 phosphorylation and STAT-DNA binding Based on physicochemical properties' analyses, our data suggest that moieties with acidic pKa on the small molecule may be a necessary element for mimicking the carboxyl group of Asp35 in IRRP-1 Our data confirm the relevance of this strategy of molecular mimicry of ligand-receptor interaction domains of protein partners for small molecule drug discovery

Synthesis and biological activities of 4-oxo thiazolidine derivatives

A series of 4-oxo-2-phenyl-thiazolidin-3-yl derivatives 5a-l have been obtained by cyclisation of various Schiff's base 4 with thioglycolic acid. The Schiff's base 4 are obtained by the reaction of appropriate carbonyl compound with (4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-yl-sulfanyl)-acetic acid hydrazide 3. The product is characterized by spectral and analytical data. Most of the tested compounds show promising antibacterial and antifungal activity.