370857-83-3

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 103213-32-7 N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 505076-77-7 9-fluorenylmethoxycarbonyl-Cys(trityl)-OH 
• 1336805-11-8 (R,E)-benzyl 4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(tritylthio)pent-2-enoate 
• 370857-88-8 N-((R)-2-(4-Bromo-butylsulfanyl)-1-{(S)-1-[(R)-1-(methoxy-methyl-carbamoyl)-2-tritylsulfanyl-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-benzamide 
• 370857-84-4 {(S)-1-[(R)-1-(Methoxy-methyl-carbamoyl)-2-tritylsulfanyl-ethylcarbamoyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 370857-87-7 N-((R)-2-Mercapto-1-{(S)-1-[(R)-1-(methoxy-methyl-carbamoyl)-2-tritylsulfanyl-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-benzamide 
• 370857-89-9 (3R,6S,9R)-9-Benzoylamino-6-methyl-5,8-dioxo-1,11-dithia-4,7-diaza-cyclopentadecane-3-carboxylic acid methoxy-methyl-amide 

Relevant academic research and scientific papers

Rational Design of a DNA-Scaffolded High-Affinity Binder for Langerin

Binders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amoun

Synthesis of α, β-unsaturated γ-amino esters with unprecedented high (E)-stereoselectivity and their conformational analysis in peptides

Mild, efficient and racemization-free synthesis of N-protected α, β-unsaturated γ-amino esters with unprecedented high E- stereoselectivity is described. This method is found to be compatible with Boc-, Fmoc- and other side chain protecting groups. The crystal conformations of the vinylogous γ-amino esters in monomers and in homo- and mixed dipeptides are studied. Further, the vinylogous homo-dipeptide showed a β-sheet conformation, while mixed α- and α,β-unsaturated γ-hybrid dipeptide adapted an irregular structure in single crystals.

Synthesis of thiol-modified peptide nucleic acids designed for post-assembly conjugation reactions

Two orthogonally protected PNA monomers were prepared having the mercaptomethyl moiety attached to the PNA backbone. These building blocks were employed in solid-phase PNA synthesis and it was shown that Boc/S-p- methoxybenzyl protection scheme was only s

Solid-phase synthesis of peptide vinyl sulfones as potential inhibitors and activity-based probes of cysteine proteases

(Matrix presented) Peptide vinyl sulfones were prepared from 2-chlorotrityl resin-bound phenolic amino vinyl sulfones in high yield and purity. This method enables the convenient synthesis of peptide vinyl sulfones having different amino acids at the Psu

General method for the synthesis of cyclic peptidomimetic compounds

A number of cyclic peptides, wherein the i and i+1 residue side chains are joined by an alkyl linker and a Weinreb amide is present at the C-terminus, were synthesized. Using LiCl to solubilize these peptides in THF the C-terminus can be readily converted to an activated carbonyl such as an aldehyde or ketone.