37118-19-7

Basic information

• Product Name: Oxazole, 4-[(4-methylphenyl)sulfonyl]-5-phenyl-
• CAS NO: 37118-19-7
• Molecular Formula: C16H13NO3S
• Molecular Weight: 299.35
• Mol File: 37118-19-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Oxazole, 4-[(4-methylphenyl)sulfonyl]-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 4-[(4-methylphenyl)sulfonyl]-5-phenyl-(37118-19-7)
• EPA Substance Registry System: Oxazole, 4-[(4-methylphenyl)sulfonyl]-5-phenyl-(37118-19-7)

Safety Data

• Hazardous Substances Data: 37118-19-7(Hazardous Substances Data)

Upstream product

• 93-89-0 benzoic acid ethyl ester 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 98-88-4 benzoyl chloride 
• 13079-28-2 benzoic toluene-p-sulphonic anhydride 
• 65-85-0 benzoic acid 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 1006-68-4 5-phenyloxazole 

Relevant articles and documents

A simple and efficient method for the synthesis of 4-tosyloxazoles from tosylmethyl isocyanide with a-ketoimidoyl chlorides

An efficient one-pot method for the synthesis of potentially biologically active 4-tosyloxazole derivatives is described via reaction of imidoyl chloride adducts generated in situ from the reaction of isocyanide and acyl chlorides with p-toluenesulfonylmethyl isocyanide (TosMIC). This reaction was carried out in the presence of sodium hydride as a base and in THF to produce 4-tosyloxazoles in excellent yield.

Highly diastereo- and enantioselective silver-catalyzed double [3+2] cyclization of α-imino esters with isocyanoacetate

Presented herein is a new complexity-generating method in which both functionalities of α-imino esters undergo stereoselective cyclization with isocyanoacetates to produce directly linked oxazole-imidazolines, which can be transformed into highly functionalized α,β-diamino esters and imidazolinium salts in high diastereo- and enantiopurity. Double up: An unprecedented silver-catalyzed title reaction has been developed and provides access to directly linked oxazole-imidazolines. A highly diastereo- and enantioselective variant was also realized using the catalyst Ag/L*. The products can be easily transformed into highly functionalized chiral α,β-diamino esters or imidazolinium salts which are useful motifs in asymmetric synthesis and catalysis.

Synthesis of thiazoles and imidazoles from isothiocyanates and tosylmethyl isocyanide. Base-induced ring transformation of 5-amino-1,3-thiazoles to imidazole-5-thiols

Base-induced cycloadditions of tosylmethyl isocyanide to a series of isothiocyanates have been investigated.Depending on the reaction conditions, thiazoles 5 and/or imidazoles 7 are obtained, with the thiazoles, in particular, being obtained with high reg