3716-66-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(1-Adamantylamino)-1-ethanol is used as a key intermediate for the synthesis of various pharmaceutical drugs. Its adamantane moiety and hydroxyl group provide unique structural features that can enhance the pharmacological properties of the resulting drug molecules, such as improving their stability, solubility, and bioavailability.
Used in Organic Synthesis:
2-(1-Adamantylamino)-1-ethanol is used as a building block in organic synthesis for the creation of complex organic molecules. Its adamantane framework and reactivity make it a valuable component in the synthesis of a wide range of compounds, including natural products, pharmaceuticals, and other biologically active molecules.
Used in Materials Science:
2-(1-Adamantylamino)-1-ethanol has potential applications in materials science due to its distinctive structure and reactivity. Its adamantane moiety can contribute to the development of new materials with unique properties, such as improved thermal stability, mechanical strength, or self-assembly capabilities.
Used in Chemical Research:
2-(1-Adamantylamino)-1-ethanol is utilized in chemical research to explore its reactivity and potential applications in various chemical reactions. Its unique structure allows researchers to investigate new synthetic routes, reaction mechanisms, and the development of novel catalysts or reagents.

InChI:InChI=1/C12H21NO/c14-2-1-13-12-6-9-3-10(7-12)5-11(4-9)8-12/h9-11,13-14H,1-8H2

Upstream product

• 75-21-8 oxirane 
• 665-66-7 amantadine hydrochloride 
• 768-94-5 1-Adamantanamine 
• 79750-14-4 N-benzyl-N-(2-hydroxyethyl)-1-adamantylamine 
• 768-90-1 1-Adamantyl bromide 
• 141-43-5 ethanolamine 
• 3717-60-0 2-[N-(1-adamantyl)]aminomethylbenzene 
• 624-76-0 Iodoethanol 
• 24569-89-9 1,3-dehydroadamantane 

Relevant academic research and scientific papers

Chemical Transformations of Tetracyclo[3.3.1.13,7.01,3]decane (1,3-Dehydroadamantane): VII. Reaction of 1,3-Dehydroadamantane with Alkanediols and Amino Alcohols

The reaction of 1,3-dehydroadamantane with C2–C6 α,ω-alkanediols selectively afforded ω-(adamantan- 1-yloxy)alkan-1-ols in 87–94% yield. The reaction of 1,3-dehydroadamantane with ω-aminoalkan-1- ols (2-aminoethanol and 3-aminopropan-1-ol) gave mixtures of addition products through the oxygen and nitrogen atoms, which can be readily separated by fractional vacuum distillation or crystallization.

N-Heterocyclic Carbene Complexes, Their Preparation And Use

Described are N-heterocyclic carbene complexes of the formula I, where n is 0 or 1, M is a metal atom containing group, R1 is selected from hydrogen alkyl, cycloalkyl, heterocycloalkyl, aryl and hetaryl, R2 is selected from hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl and hetaryl, wherein R1 and R2 do not both stand for hydrogen. Furthermore, also described are methods for their preparation and their use as catalysts employed in a C—C, C—O, C—N or C—H bond formation reaction.

N-HETEROCYCLIC CARBENE COMPLEXES, THEIR PREPARATION AND USE

N-heterocyclic carbene complexes of the formula (I) is disclosed, wherein the radicals have the meanings as defined in the invention. The preparation and the use as catalysts employed in a C-C, C-O, C-N or C-H bond formation reaction of said complexes are also disclosed.

Carbenes made easy: Formation of unsymmetrically substituted N-heterocyclic carbene complexes of palladium(II), platinum(II) and gold(I) from coordinated isonitriles and their catalytic activity

From palladium(II) or platinum(II) bis(isonitrile) complexes and from gold(I) isonitrile complexes, both easily available from simple precursors, the corresponding mono-N-heterocyclic carbene (NHC) complexes could be obtained selectively in good yields under very mild conditions. The reagents are simple β-chloroammonium salts in the presence of a weak base. Unsymmetric NHC complexes are accessible. Thus over only two steps from simple metal precursors a broad variety of NHC complexes is available, the method is ideal to quickly assemble catalyst libraries. The palladium complexes are active pre-catalysts in Suzuki cross-coupling even with the additional isonitrile ligand on palladium. Copyright

DERIVATIVES OF ADAMANTANE. I. 2-HYDROXYETHYLAMINO DERIVATIVES OF ADAMANTANE

The reaction of 1-bromoadamantane with hydroxyalkylamines leads to the preferential formation of 1-(aminoalkoxy)adamantanes.The 2-hydroxyethylamino derivatives of the adamantane series were obtained by the reaction of ethylene oxide with the corresponding amines.