3724-16-1

Basic information

• Product Name: 2-(PYRIDIN-3-YL)ACETAMIDE
• Synonyms: 2-(PYRIDIN-3-YL)ACETAMIDE;3-Pyridineacetamide, 99%;2-(pyridin-3-yl)acetamid
• CAS NO: 3724-16-1
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• Mol File: 3724-16-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 122-124°C
• Boiling Point: 360.3°C at 760 mmHg
• Flash Point: 171.7°C
• Appearance: /
• Density: 1.17
• Vapor Pressure: 2.25E-05mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-(PYRIDIN-3-YL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PYRIDIN-3-YL)ACETAMIDE(3724-16-1)
• EPA Substance Registry System: 2-(PYRIDIN-3-YL)ACETAMIDE(3724-16-1)

Safety Data

• Hazardous Substances Data: 3724-16-1(Hazardous Substances Data)

Usage

General Description

2-(pyridin-3-yl)acetamide is a chemical compound with the molecular formula C8H8N2O. It is a white crystalline solid that is often used in research and pharmaceutical applications. 2-(PYRIDIN-3-YL)ACETAMIDE is a derivative of acetamide and contains a pyridine ring, which makes it useful for targeting specific receptors in biological systems. It has been studied for its potential medicinal properties and may have applications in drug development for conditions such as neurological disorders and cancer. Additionally, it is used as a building block in organic synthesis and can be found in various chemical databases for reference and research purposes.

InChI:InChI=1/C7H8N2O/c8-7(10)4-6-2-1-3-9-5-6/h1-3,5H,4H2,(H2,8,10)

Upstream product

• 39998-25-9 methyl pyridine-3-acetate 
• 6443-85-2 3-pyridinylacetonitrile 
• 501-81-5 pyridyl-3-yl-acetic acid 
• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 34672-31-6 [3]pyridyl-acetone oxime 
• 71271-61-9 (+/-)-1-(3-pyridyl)propan-2-amine 
• 6302-03-0 1-(pyridin-3-yl)-2-propanone 
• 100-54-9 pyridine-3-carbonitrile 
• 6443-85-2 3-pyridinylacetonitrile 

Relevant articles and documents

Hydration of Aliphatic Nitriles Catalyzed by an Osmium Polyhydride: Evidence for an Alternative Mechanism

The hexahydride OsH6(PiPr3)2 competently catalyzes the hydration of aliphatic nitriles to amides. The main metal species under the catalytic conditions are the trihydride osmium(IV) amidate derivatives OsH3{κ2-N,O-[HNC(O)R]}(PiPr3)2, which have been isolated and fully characterized for R = iPr and tBu. The rate of hydration is proportional to the concentrations of the catalyst precursor, nitrile, and water. When these experimental findings and density functional theory calculations are combined, the mechanism of catalysis has been established. Complexes OsH3{κ2-N,O-[HNC(O)R]}(PiPr3)2 dissociate the carbonyl group of the chelate to afford κ1-N-amidate derivatives, which coordinate the nitrile. The subsequent attack of an external water molecule to both the C(sp) atom of the nitrile and the N atom of the amidate affords the amide and regenerates the κ1-N-amidate catalysts. The attack is concerted and takes place through a cyclic six-membered transition state, which involves Cnitrile···O-H···Namidate interactions. Before the attack, the free carbonyl group of the κ1-N-amidate ligand fixes the water molecule in the vicinity of the C(sp) atom of the nitrile.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Cyanoamidine P2X7 antagonists for the treatment of pain

Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.