3733-29-7

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. Symmetrical compound

Explanation

The compound has a balanced structure with two identical halves, making it symmetrical.
3. Contains two bromomethyl groups

Explanation

Bromomethyl groups are functional groups containing a bromine atom and a methyl group (CH3) attached to the dioxane ring.
4. Dioxane ring

Explanation

A six-membered heterocyclic organic compound composed of two oxygen atoms and four carbon atoms.
5. Crosslinking agent

Explanation

Used in the production of polymers and resins to create a network of chemical bonds between polymer chains, improving the material's strength and stability.
6. Reagent in organic synthesis

Explanation

Employed as a starting material or intermediate in the synthesis of various organic compounds.
7. Potential environmental hazard

Explanation

The compound may have negative effects on the environment due to its chemical properties and potential for contamination.
8. Toxic effects on human health

Explanation

Exposure to the compound can lead to adverse health effects, necessitating proper handling and safety precautions.
9. Proper handling and safety precautions

Explanation

Due to its potential hazards, it is crucial to follow safety guidelines and protocols when working with 1,3-Dioxane, 5,5-bis(bromomethyl)-2-phenyl-, such as using personal protective equipment and ensuring proper ventilation.

Upstream product

• 100-52-7 benzaldehyde 
• 115-77-5 Pentaerythritol 
• 3296-90-0 bis(bromomethyl)bis(hydroxymethyl)methane 

Downstream Products

• 142733-60-6 2,2‐diethyl 7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylate 
• 1053178-83-8 bis-(diethyl malonate)monobenzalpentaerythritol 
• 1237542-07-2 diisopropyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate 
• 77614-64-3 7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylic acid 

Relevant academic research and scientific papers

Nitroxide derivative of ROCK kinase inhibitor

The invention provides a small molecular compound of a NO donor. The small molecular compound is characterized in that the small molecular compound is a compound shown represented by structural formula I shown in the description, or a stereoisomer, a geometrical isomer, a tautomer, a racemate, a deuterated isotope derivative, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof; and in the formula I, ring A is a substituted or unsubstituted heteroaromatic ring, X is selected from (CH2)n, n is selected from 0, 1, 2 and 3, R is a substituent group of terminal -O-NO2, R is selected from hydrogen, a hydroxyl group, halogen, an amino group, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group and a substituted or unsubstituted heteroalkyl group, and R and R are respectively and independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted naphthenic base or an amino protecting group, or R and R are connected to form a substituted or unsubstituted cyclic heteroalkyl group. The compound has a high-activity inhibition effect on ROCK kinase.

Efficient synthesis of 6-amino-2-thiaspiro[3,3]heptane hydrochloride

A novel compound 6-amino-2-thiaspiro[3,3]heptane hydrochloride was synthesized in nine steps using 2,2-bis(bromomethyl)-1,3-propanediol as starting material, with an overall yield of 31%.

Host-guest complexes of cucurbit[8]uril with some pentaerythritol derivative guests

A series of first generation dendritic guests from pentaerythritol derivatives have been designed and synthesized. Investigation of the complex structures of cucurbit[8]uril (Q[8]) and the guests based on the 1H NMR technique have revealed that the host Q[8] selectively included different branch(es) of the first generation dendritic guests and formed inclusion complexes with different structural conformations. The experimental results obtained from electronic absorption spectroscopy showed that the 1:1 ratio of Q[8]-based host-guest inclusion complexes have moderate stability with an average formation constants of 104 L mol-1. The single crystal structures of some of the guests (g5 and g6) and Q[8]-guest complexes (Q[8]-g4 and Q[8]-g6) further confirm but in some cases contradict the research results of the 1H NMR technique and electronic absorption spectroscopy in aqueous solution. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2011.

Synthesis of 2-azaspiro[3.3]heptane-derived amino acids: Ornitine and GABA analogues

Synthesis of 6-amino-2-azaspiro[3.3]heptane-6-carboxylic acid and 2-azaspiro[3.3]heptane-6-carboxylic acid was performed. Both four-membered rings in the spirocyclic scaffold were constructed by subsequent ring closure of corresponding 1,3-bis-electrophil

Cyclobutane-derived diamines: Synthesis and molecular structure

Cyclobutane diamines (i.e., cis- and trans-1,3-diaminocyclobutane, 6-amino-3-azaspiro[3.3]heptane, and 3,6-diaminospiro[3.3]heptane) are considered as promising sterically constrained diamine building blocks for drug discovery. An approach to the syntheses of their Boc-monoprotected derivatives has been developed aimed at the preparation of multigram amounts of the compounds. These novel synthetic schemes exploit classical malonate alkylation chemistry for the construction of cyclobutane rings. The conformational preferences of the cyclobutane diamine derivatives have been evaluated by X-ray diffraction and compared with the literature data on sterically constrained diamines, which are among the constituents of commercially available drugs.

ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF

The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents.

1-(1-CYCLOBUTYL-4-PIPERIDINYL)-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE ML RECEPTOR AND THEIR USE IN MEDICINE

Compounds of formula I or a salt thereof are provided wherein R4, R5, R6, Q, L and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders and cognitive impairments are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Cationic complexes of technetium-99m

The invention concerns cationic complexes of Technetium-99m with bidentate ligands (L), including complexes having the formulae [Tc(NO) X L2 ]+ and [Tc L3 ]+, which are of interest as heart imaging agents. The ligands are characterized by having the formula Y2 QZQY2, where each Q is phosphorus or arsenic, Z is a 2 or 3 carbon atom linking group, and at least one of the groups Y and Z includes at least one --COC--ether group.