37418-64-7

Upstream product

• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 62-53-3 aniline 
• 41125-10-4 benzoylacetaldehyde sodium salt 
• 142-04-1 aniline hydrochloride 
• 615-43-0 2-iodophenylamine 
• 3623-15-2 phenyl propargyl ketone 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 93-55-0 1-phenyl-propan-1-one 
• 98-86-2 acetophenone 
• 19518-12-8 1-(3-oxo-3-phenyl-propenyl)-pyridinium; chloride 
• 99647-89-9 1-phenyl-2,3-dibromo-3-methylnitroamino-1-propanone 
• 103-72-0 phenyl isothiocyanate 
• 99647-88-8 1-phenyl-3-(methylnitroamino)-2-propen-1-one 
• 99647-90-2 1-phenyl-3-butylnitroamino-2-propen-1-one 

Downstream Products

• 1010796-69-6 N-(3-oxo-3-phenylpropenyl)-N-phenyloxalamic acid ethyl ester 
• 1010796-70-9 2,2,2-trifluoro-N-(3-oxo-3-phenylpropenyl)-N-phenylacetamide 

Relevant academic research and scientific papers

Multi-substituted pyrrole derivative and preparation method thereof

The invention discloses a multi-substituted pyrrole derivative and a preparation method thereof, and relates to the field of organic synthesis. According to the preparation method, diazonium or phenylhydrazone reacts with amino substituted unsaturated car

A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism

An efficient method for the preparation of β-amino-α,β-unsaturated carbonyl compounds is demonstrated. Bench-stable sodium 3-oxo-enolates were prepared from carbonyl compounds, and reacted with amines in the presence of an acid and a desiccant. DFT studie

Compounds containing N-alpha, beta unsaturated ketone and preparation method and application of compounds

The invention belongs to the technical field of organic synthesis and particularly relates to compounds containing N-alpha, beta unsaturated ketone and a preparation method and application of the compounds. The preparation method includes: dissolving a co

Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis

An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).

Nickel-catalyzed cyclization of 2-iodoanilines with aroylalkynes: An efficient route for quinoline derivatives

An efficient and convenient nickel-catalyzed cyclization of 2-iodoanilines with alkynyl aryl ketones to give 2,4-disubstituted quinolines was developed. The reaction can be employed for the synthesis of naturally occurring quinoline derivatives in good yields. On the basis of the regiochemistry of the products, the possible pathway for the reaction is via the formation of o-aminochalcone.

Enaminones in heterocyclic synthesis: A novel route to polyfunctionalized substituted thiophene, 2,3-dihydro-1,3,4-thiadiazole and naphtho[1,2-b] furan derivatives

The enaminones 1a,b reacted with phenylisothiocyanate to afford the thioanilides 2a,b. The latter could be utilized to synthesize several new polysubstituted thiophenes 9a-f, and 1,3,4-thiadiazoles 12a-f.

Deuterium isotope effects on 13C chemical shifts of enaminones

Deuterium isotope effects on 13C chemical shifts have been studied in a series of substituted N-alkyl and N-phenyl keto-enamines. The intramolecularly hydrogen bonded Z-forms show the largest two-bond isotope effects, 2δC-1 (ND). Methyl-substitution at C-1 leads to a larger two-bond isotope effect in the N-phenyl-substituted derivatives. This effect is ascribed to steric compression. Space-filling substituents at the ortho-position of the N-phenyl ring lead to a decrease of the two-bond isotope effect. A correlation is found between 2δC-1(ND) and 3δC-2′(ND). The latter becomes negative in the sterically hindered cases. 3δC-2′(ND) may therefore be used as a gauge of the twist of the phenyl ring. o-Hydroxy substitution of the CO-phenyl rings enables intramolecular hydrogen bonding to the carbonyl group. This kind of hydrogen bond with two donors to one acceptor leads to smaller 2δC-2(ND) and 2δC-2″(OD) isotope effects equivalent to weaker hydrogen bonds for the Z-isomer. This is ascribed to competition for the acceptor. For the E-isomer 2δC(OD) is enhanced. The same feature is seen for N,N-dimethylamino enamines. This increase is ascribed to delocalization of the nitrogen lone-pair onto the carbonyl oxygen, thereby strengthening the hydrogen bond and thus leading to larger two-bond, 2δC(OD), isotope effects. Acta Chemica Scandinavica 1997.

ACETALS OF LACTAMS AND ACID AMIDES. 67. POLAROGRAPHIC BEHAVIOR OF ENAMINES OF THE INDOLES SERIES IN ANHYDROUS DMF

The polarographic behavior of derivatives of 2-aminomethyleneindoxyl and 3-aminomethyleneoxindole in anhydrous DMF has been studied and the results compared with data on the polarographic reduction of substituted aminomethyleneacetophenones and of related

SOME PROPERTIES OF UNSATURATED NITROAMINES

In the reaction of ketovinylnitroamines with various nucleophiles substitution of the nitroamine group by the nucleophilic reagent took place in all cases.The addition of bromine at the double bond of ketovinylnitroamines took place with difficulty after prolonged heating in benzene or carbon tetrachloride.