
Archiv der Pharmazie p. 383 - 389 (1993)
Update date:2022-08-05
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Lessel
Using acetic acid as a solvent, ketones and aromatic aldehydes react with amidoximes 1 to cyclic products, Δ2-1,2,4-oxadiazolines 3. The lack of reactivity in neutral milieu is explained by MNDO calculations. Protonated carbonyl compounds are discussed to be the reactive species.
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(1986)