3751-48-2

Basic information

• Product Name: 3-(3-METHYLPHENYL)PROPIONIC ACID
• Synonyms: 3-m-Tolylpropionic acid;m-Methylhydrocinnamic acid;HydrocinnaMic acid, M-Methyl-;3-(3-Methylphenyl)propionic acid, 96%, 96%;3-METHYLHYDROCINNAMIC ACID;3-(3-METHYLPHENYL)PROPANOIC ACID;3-(3-METHYLPHENYL)PROPIONIC ACID;Propionic acid, 3-[3-methylphenyl]-
• CAS NO: 3751-48-2
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 3751-48-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 39-42 °C(lit.)
• Boiling Point: 290℃
• Flash Point: >230 °F
• Appearance: /
• Density: 1.097
• Vapor Pressure: 0.000986mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetone, DMSO, Methanol
• PKA: pK1:4.677 (25°C)
• CAS DataBase Reference: 3-(3-METHYLPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-METHYLPHENYL)PROPIONIC ACID(3751-48-2)
• EPA Substance Registry System: 3-(3-METHYLPHENYL)PROPIONIC ACID(3751-48-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-41-36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 3751-48-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

3-m-Tolylpropanoic Acid is used in the synthesis of piperidine antagonists as CCR1-selective inhibitors. via parallel synthesis. Also used in the synthesis of small molecule antagonists of vasoactive intestinal. peptide receptor1 (VIPR1).

InChI:InChI=1/C10H12O2/c1-8-3-2-4-9(7-8)5-6-10(11)12/h2-4,7H,5-6H2,1H3,(H,11,12)

Upstream product

• 57-57-8 β-Propiolactone 
• 591-17-3 meta-bromotoluene 
• 100-80-1 3-methylstyrene 
• 124-38-9 carbon dioxide 
• 3495-36-1 cesium formate 
• 64-18-6 formic acid 
• 16799-08-9 1-(2-bromoethyl)-3-methylbenzene 
• 201230-82-2 carbon monoxide 
• 58686-70-7 ethyl 3-(m-tolyl)propiolate 
• 141-82-2 malonic acid 
• 620-23-5 m-tolyl aldehyde 
• 620-13-3 1-bromomethyl-3-methyl-benzene 
• 251963-44-7 Dimethyl 2-(3-methylbenzyl)malonate 
• 620-19-9 1-chloromethyl-3-methyl-benzene 

Downstream Products

• 29417-96-7 3-methyldihydrocinnamic acid methyl ester 
• 1176925-48-6 2-bromo-5-methoxy-3-(3-methylphenethyl)naphthalene-1,4-dione 
• 39627-61-7 7-methyl-1-indanone 
• 4593-38-8 5-methylindan-1-one 
• 20150-83-8 6-methyl-1,2,3,4-tetrahydroquinolin-2-one 
• 1251303-74-8 C₁₀H₁₃NO₂ 
• 20151-47-7 8-methyl-3,4-dihydroquinolin-2(1H)-one 
• 111171-85-8 1-iodo-3-(m-methylphenyl)propane 

Relevant articles and documents

Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer

A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

Site-Selective, Remote sp3 C?H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis

A photoinduced carboxylation of alkyl halides with CO2 at remote sp3 C?H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.