39627-61-7

Usage

Uses

Used in Fragrance Industry:
7-Methyl-1-Indanone is used as a fragrance ingredient for its sweet, floral scent, enhancing the aroma of perfumes and other scented products.
Used in Pharmaceutical Industry:
7-Methyl-1-Indanone is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Organic Synthesis:
7-Methyl-1-Indanone serves as a building block in the synthesis of other organic compounds, playing a crucial role in the creation of diverse chemical products.
Safety Considerations:
While 7-Methyl-1-Indanone is a valuable chemical compound, it is important to note that it may be harmful if swallowed, and exposure to the skin or eyes can cause irritation. Proper handling and safety measures should be taken during its use in various applications.

InChI:InChI=1/C10H10O/c1-7-3-2-4-8-5-6-9(11)10(7)8/h2-4H,5-6H2,1H3

Upstream product

• 3751-48-2 3-(3-methylphenyl)propanoic acid 
• 39627-60-6 1-(2-methylphenyl)-2-propen-1-one 
• 103040-39-7 3-(3-methylphenyl)propionyl chloride 
• 3029-79-6 3-methylcinnamic acid 
• 620-19-9 1-chloromethyl-3-methyl-benzene 
• 118-90-1 ortho-methylbenzoic acid 
• 3377-20-6 diethyl methylenemalonate 
• 50-00-0 formaldehyd 
• 84450-90-8 2-methylbenzoic acid-6-d₁ 
• 108-59-8 malonic acid dimethyl ester 
• 618084-94-9 2,2-dimethyl-5-(3-methylbenzyl)-1,3-dioxane-4,6-dione 
• 83586-04-3 7t-Methyl-(3arH,7atH)-3a,4,7,7a-tetrahydro-indanon-⁽¹⁾ 
• 78-94-4 methyl vinyl ketone 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 

Downstream Products

• 763027-02-7 7-Methyl-indan-1-on-amidinohydrazon 
• 113649-25-5 2,3-Dihydro-2-(3-methoxy-5-methylbenzyliden)-7-methyl-1H-inden-1-on 
• 113649-26-6 2,3-Dihydro-2-(3-methoxy-5-methylbenzyl)-7-methyl-1H-inden-1-on 
• 113649-27-7 2,3-Dihydro-2,2-bis(3-methoxy-5-methylbenzyl)-7-methyl-1H-inden-1-on 
• 113649-28-8 2-(3,5-Dimethoxybenzyl)-2,3-dihydro-2-(3-methoxy-5-methylbenzyl)-7-methyl-1H-inden-1-on 
• 7251-82-3 3-Methylphthalimide 
• 1297598-92-5 2-(4-fluorobenzylidene)-7-methylindan-1-one 
• 1297598-96-9 [9-bromomethyl-4-(4-fluorophenyl)-5-oxo-5H-indeno[1,2-d]pyrimidin-2-yl]-bis-carbamic acid tert-butyl ester 
• 1297598-95-8 [4-(4-fluorophenyl)-9-methyl-5-oxo-5H-indeno[1,2-d]pyrimidin-2-yl]-bis-carbamic acid tert-butyl ester 
• 1297598-97-0 2-amino-9-bromomethyl-4-(4-fluoro-phenyl)-indeno[1,2-d]pyrimidin-5-one 
• 1297598-88-9 2-Amino-9-(2,4-dimethyl-thiazol-5-ylmethyl)-4-(4-fluoro-phenyl)-indeno[1,2-d]pyrimidin-5-one 
• 1297598-94-7 2-amino-4-(4-fluoro-phenyl)-9-methyl-indeno[1,2-d]pyrimidin-5-one 
• 1297598-93-6 4-(4-fluoro-phenyl)-9-methyl-5H-indeno[1,2-d]pyrimidin-2-ylamine 
• 461641-22-5 5-methyl-4-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis method of indanone derivatives

The present invention provides a synthesis method of indanone derivatives. The synthesis method comprises the following steps: adding a benzoic acid compound, an acrylate compound, a rhodium catalyst and an alkali to an organic solvent, heating under a nitrogen gas condition to carry out a reaction, and after the reaction is complete, carrying out post-treatment to obtain 2-substituted indanone compounds. According to the synthesis method of the indanone derivatives, one-step synthesis of the indanone products from the benzoic acid compound and the acrylic ester compound is realized; and the method is simple and convenient to operate, good in functional group compatibility and high in reaction yield.

Synthesis method of 1-indanone compounds

The present invention provides a synthesis method of 1-indanone compounds. The method comprises the following steps: adding benzoic acid compounds, dimethyl malonate, paraformaldehyde, a rhodium catalyst and an alkali to an organic solvent, heating under a nitrogen gas condition to carry out a reaction, and after the reaction is complete, carrying out post-treatment to obtain the 1-indanone compounds. The provided synthesis method of the 1-indanone compounds is simple and convenient to operate, the substrate is cheap and easy to obtain, wide in universality and good in functional group compatibility, and a simple and efficient method is provided for synthesizing indanone derivatives with diversified structures.

Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent.

Rhodium-Catalyzed Annelation of Benzoic Acids with α,β-Unsaturated Ketones with Cleavage of C?H, CO?OH, and C?C Bonds

In the presence of a [Cp*RhCl2]2 catalyst, the Lewis acid In(OTf)3, and the mild base Na2CO3, aromatic carboxylates and α,β-unsaturated ketones undergo a unique hydroarylation/Claisen/retro-Claisen pr

Non-conventional methodologies in the synthesis of 1-indanones

1-Indanones have been successfully prepared by means of three different non-conventional techniques, namely microwaves, high-intensity ultrasound and a Q-tube reactor. A library of differently substituted 1-indanones has been prepared via one-pot intramolecular Friedel-Crafts acylation and their efficiency and "greenness" have been compared.

The design and synthesis of novel IBiox N-heterocyclic carbene ligands derived from substituted amino-indanols

A synthetic route towards a number of novel IBiox N-heterocyclic carbene (NHC) ligands has been developed. The resulting ligands have restricted flexibility and high steric demand. Preliminary studies have shown these ligands to give high levels of asymmetric induction in the copper-free allylic alkylation of cinnamyl bromide.

Asymmetric synthesis of chiral 1,3-diaminopropanols: Bisoxazolidine- catalyzed C-C bond formation with α-keto amides

Three high-yielding steps lead to the formation of chiral 1,3-diaminopropanols from aliphatic and aromatic α-keto amides. In this approach, a nitroaldol reaction, which is catalyzed by Cu(SO2CF 3)2 and the bisoxazolidine ligand L1, is followed by two mild reduction reactions (see scheme). Laborious protection and deprotection steps can be avoided by using this method.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

Synthesis of indanones via solid-supported [2+2+2] cyclotrimerization

(Chemical Equation Presented) A new facile approach toward natural and unnatural indanones has been developed, featuring a solid-supported [2+2+2] cyclotrimerization as the key step. This strategy has been applied to the chemo- and regioselective assembly of indanone arrays and to the total synthesis of a recently isolated indanone marine natural product.

Meldrum's acids as acylating agents in the catalytic intramolecular Friedel-Crafts reaction

(Chemical Equation Presented) The intramolecular Friedel-Crafts acylation of aromatics with Meldrum's acid derivatives catalyzed by metal trifluoromethanesulfonates is reported. Meldrum's acids are easily prepared, functionalized, handled, and purified. The synthesis of polysubstituted 1-indanones from benzyl Meldrum's acids was investigated thoroughly, and it was shown that a variety of catalysts were effective, while accommodating a diversity of functional groups under mild conditions. The scope, limitations, and functional group tolerance (terminal alkene and alkyne, ketal, dialkyl ether, dialkyl thioether, aryl methyl ether, aryl TIPS and TBDPS ethers, nitrile- and nitro-substituted aryls, alkyl and aryl halides) for a variety of 5-benzyl (enolizable Meldrum's acids) and 5-benzyl-5-substituted Meldrum's acids (quaternized Meldrum's acids), forming 1-indanones and 2-substituted-1- indanones, respectively, are delineated. This method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil. Rate of cyclization as a function of ring size was established for various benzocyclic ketones via competition experiments: 1-tetralones form faster than both 1-indanones and 1-benzosuberones, and 1-benzosuberones cyclize faster than 1-indanones.