720665-79-2Relevant academic research and scientific papers
SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors
Liu, Luping,Stelmach, John E.,Natarajan, Swaminathan R.,Chen, Meng-Hsin,Singh, Suresh B.,Schwartz, Cheryl D.,Fitzgerald, Catherine E.,O'Keefe, Stephen J.,Zaller, Dennis M.,Schmatz, Dennis M.,Doherty, James B.
, p. 3979 - 3982 (2007/10/03)
Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido(3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets
