37593-03-6Relevant academic research and scientific papers
Reevaluation of the Palladium/Carbon-Catalyzed Decarbonylation of Aliphatic Aldehydes
Ajda?i?, Vladimir,Nikoli?, Andrea,Kerner, Michael,Wipf, Peter,Opsenica, Igor M.
supporting information, p. 1781 - 1785 (2018/08/12)
An improved method for the decarbonylation of aliphatic aldehydes by using a commercially available Pd/C catalyst is described. The reaction conditions are suitable for linear, cyclic, or sterically demanding substrates, as they afford the corresponding alkanes in yields of up to 99%. In addition, this Pd/C-catalyzed method exhibits good functional-group tolerance. A comparison of previously reported methods with the present one showed that the reaction conditions play a crucial role in the outcome of the reaction. The method can also be applied in a two-step reaction sequence for the synthesis of industrially important compounds.
Small molecule suppression of carbapenem resistance in ndm-1 producing klebsiella pneumoniae
Worthington, Roberta J.,Bunders, Cynthia A.,Reed, Catherine S.,Melander, Christian
supporting information; experimental part, p. 357 - 361 (2012/07/01)
The already considerable global public health threat of multidrug-resistant Gram-negative bacteria has become even more of a concern following the emergence of New Delhi metallo-β-lactamase (NDM-1) producing strains of Klebsiella pneumoniae and other Gram-negative bacteria. As an alternative approach to the traditional development of new bactericidal entities, we have identified a 2-aminoimidazole-derived small molecule that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae to imipenem and meropenem, in addition to suppressing resistance of other β-lactam nonsusceptible K. pneumoniae strains. The small molecule is able to lower carbapenem minimum inhibitory concentrations by up to 16-fold, while exhibiting little bactericidal activity itself.
Zn-mediated, Pd-catalyzed cross-couplings in water at room temperature without prior formation of organozinc reagents
Krasovskiy, Arkady,Duplais, Christophe,Lipshutz, Bruce H.
supporting information; experimental part, p. 15592 - 15593 (2010/01/30)
(Chemical Equation Presented) Mix in water, stir. That is all that is required in this new approach to sp3-sp2 cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under cata
Specific interactions in discotic liquid crystals
Kouwer, Paul H. J.,Jager, Wolter F.,Mijs, Wim J.,Picken, Stephen J.
, p. 458 - 469 (2007/10/03)
A series of novel mesogens have been prepared by a five-fold Sonogashira reaction of terminal acetylenes with a functionalized pentabromophenol derivative. The corresponding side-chain substituted polymers were prepared by an analogous polymer substitution reaction. The mesogens differ in the nature of the substituents, i.e. CH2, O, S, SO2 and CONH groups, linking five hexyl tails to the core. A wide range of mesophases and corresponding transition temperatures have been detected, varying from low melting nematic phases to highly stable columnar phases. The wide spread in phase behaviour is described in terms of specific intermolecular interactions. The addition of planar electron deficient molecules resulted in the formation of charge transfer complexes. The observed stabilisation or destabilisation of the mesophases is explained by considering the complexation strength of the complex as well as steric factors.
The Synthesis of 3-Aryl-6-alkylpyridazines
Liang, Jason
, p. 1297 - 1299 (2007/10/02)
Nine compounds of general structure R-X-Y-R' where X is a para-disubstituted phenyl ring and Y is a 3,6-disubstituted-pyridazine ring were synthesized.These can be used as liquid crystal dopents.A general procedure for their synthesis was developed.N-Alkyl benzene and ethyl butyrylacetate were used as starting materials.The purification of reaction intermediates was not necessary if preparative hplc was used to purify the final products.Very pure materials were obtained with good yield.Their structure was confirmed by carbon 13 nmr.
Multiple Melting Behaviour in Square-planar trans-Bis-(1-p-n-alkylphenylbutane-1,3-dionato)copper(II) - The Effect of Alkyl Chain Length
Ohta, Kazuchika,Jiang, Guang-Jie,Yokoyama, Masaaki,Kusabayashi, Shigekazu,Mikawa, Hiroshi
, p. 283 - 294 (2007/10/02)
The title complexes having different n-alkyl groups from methyl to dodecyl have synthesized.All these complexes exhibit solid polymorphism.The number of polymorphs depends on the length of the alkyl chain: two for n (the number of carbon atoms) = 0-2, three for n = 3-5 and 12, and four for n = 6-11, respectively.Each polymorphic form except those with the highest m.p.s. exhibits multiple melting behaviour: double melting for n = 0-5,8, and 12, and triple melting for n = 6-11 except 8.The m.p.s. of the complexes with alkyl groups of odd carbon atoms are higher than those with even atoms, while the respective ligand solids show the opposit e even-odd effect in their m.p.s.
Study of the Influence of Molecular Length on the Characteristics of the Ordered Smectic Phase.
Benattar,Levelut,Strzelecki
, p. 1233 - 1240 (2007/10/05)
Study of DTA and X-rays of p-phenyl-benzylidene-p'-alkylanilines of mesomorphic phases demonstrates the predominant role of the aliphatic chain length. In effect, it governs the appearance of the different phases; the correlation between layers decreases for greater chain lengths. The nonlinear variations of SmB layer thickness for these compounds shows clearly the importance of steric effects coupled with the molecular length with respect to the dipolar effect.
