376594-67-1 Usage
Uses
Used in Pharmaceutical Industry:
LY 450108 is used as a research chemical for the development of novel antipsychotic drugs, targeting the treatment of schizophrenia and other psychiatric disorders. Its selective sigma receptor antagonism and unique mechanism of action differentiate it from existing antipsychotic medications, offering potential advantages in terms of efficacy and side effect profile.
Used in Preclinical Research:
In preclinical studies, LY 450108 is used as a test compound to investigate its antipsychotic and anti-amnesic properties, as well as its potential to modulate various signaling pathways involved in psychiatric disorders. These studies aim to provide insights into its mechanism of action and therapeutic potential, guiding further research and development efforts.
Used in Drug Discovery and Development:
LY 450108 serves as a lead compound in drug discovery and development programs focused on identifying and optimizing novel antipsychotic agents. Its unique pharmacological profile and promising preclinical results make it a valuable starting point for the design and synthesis of new compounds with improved safety and efficacy profiles for the treatment of schizophrenia and related psychiatric conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 376594-67-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,6,5,9 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 376594-67:
(8*3)+(7*7)+(6*6)+(5*5)+(4*9)+(3*4)+(2*6)+(1*7)=201
201 % 10 = 1
So 376594-67-1 is a valid CAS Registry Number.
376594-67-1Relevant academic research and scientific papers
Synthesis of 14C-labeled and tritiated AMPA potentiator LY450108
Czeskis, Boris A.,O'Bannon, Douglas D.,Wheeler, William J.,Clodfelter, Dean K.
, p. 85 - 100 (2007/10/03)
Asymmetric synthesis of AMPA potentiator LY450108-[14C] containing 14C-label attached to the chiral center of the molecule, was accomplished based on Evans' chiral oxazolidinone auxiliary method. Diastereoselective methylation of p-n
Sulfonamide derivatives
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Page 12, (2010/02/06)
The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders. 1
