37786-00-8

Usage

Type

Synthetic analog

Explanation

11-Deoxy Prostaglandin E1 is a synthetic version of the naturally occurring prostaglandin E1.

Explanation

It is involved in various physiological processes in the body.

Explanation

It is used in medicine for its ability to widen blood vessels and prevent blood clots.

Explanation

It is useful in treating these conditions due to its vasodilatory and antiplatelet properties.

Explanation

It works by causing the smooth muscle cells in blood vessels to relax, leading to increased blood flow and improved circulation.

Explanation

It inhibits the clumping together of platelets, reducing the risk of blood clots.

Explanation

11-Deoxy Prostaglandin E1 has important therapeutic applications in treating disorders related to the heart, blood vessels, and male reproductive system.

Function

Hormone-like substance

Medical use

Vasodilatory and antiplatelet effects

Treatment of conditions

Peripheral vascular disease and erectile dysfunction

Mechanism of action

Relaxing smooth muscle cells in blood vessels

Inhibition

Platelet aggregation

Therapeutic applications

Cardiovascular and urological disorders

InChI:InChI=1/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1

Upstream product

• 42542-00-7 (S)-3-(1-ethoxy-ethoxy)-1t-iodo-oct-1-ene 
• 34546-57-1 2-(6-methoxycarbonylhexyl)cyclopent-2-en-1-one 
• 39647-93-3 (S)-(E)-(+)-1-Iodo-1-octen-3-ol 
• 20721-87-3 (+/-)-15-epi-11-deoxy PGE₁ methyl ester 
• 39198-04-4 (E)-1-chloro-oct-1-en-3-one 
• 39178-65-9 (E)-1-iodooct-1-en-3-ol 
• 34603-80-0 15α-hydroxy-11-deoxy-8α,12β-prostaglandin-E₁ 
• 57378-32-2 15α-hydroxy-11-deoxyprostaglandin-E₁ ethyl ester 
• 23472-43-7 7-[(1S,2R)-2-((E)-(R)-3-Acetoxy-oct-1-enyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester 
• 52487-91-9 1-iodo-3-(p-anisyldiphenylmethoxy)-trans-1-octene 
• 39178-64-8 (E)-1-iodo-1-octen-3-one 
• 52477-97-1 2-(7-butoxycarbonylhexyl)-2-cyclopenten-1-one 
• 5239-43-0 7-(5-oxo-1-cyclopenten-1-yl)heptanoic acid 
• 32556-71-1 1-octyn-3-ol 

Downstream Products

• 170235-59-3 (S)-2-{7-[(1R,2R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-heptanoylamino}-3-phenyl-propionic acid 
• 170235-58-2 (S)-2-{7-[(1R,2R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-heptanoylamino}-3-phenyl-propionic acid methyl ester 
• 24341-38-6 (+/-)-15-epi-13.14-Dihydro-11-deoxy-PGE(1) 
• 5239-90-7 (+/-)-15-epi-11-deoxyprostaglandin F_1α 
• 5239-90-7 (+/-)-15-epi-11-deoxyprostaglandin F_1β 

Relevant academic research and scientific papers

CONDENSATION OF ALLYL SULFOXIDES WITH CYCLOPENTENONES IN THE SYNTHESIS OF PROSTAGLANDINS. STEREOSPECIFIC TOTAL SYNTHESIS OF 11-DEOXYPROSTAGLANDIN-E1

The reactions of the vinyl sulfoxide group in the products from the addition of the carbanions of allyl sulfoxides to cyclopentenones were investigated.The α-alkylated vinyl sulfoxide is converted

TOTAL SYNTHESIS AND PROPERTIES OF PROSTAGLANDINS. VII.* ISOMERIZATION OF(+/-)-11-DEOXYPROSTAGLANDIN-E1

Under equilibrium conditions (+/-)-11-deoxyprotaglandin-E1 exists in the form of a mixture of the 8,12-cis and 8,12-trans-isomers with a preponderance of the thermodynamically more favorable trans isomer.The 8-epimers can be converted into each other and are separated preparatively by crystallization or by chromatogratic methods.During exhaustive silylation of the isomers the same 1,9,15-tris-O-silyl derivative with an enolic C=C double bond at positions 8,9 is formed.

15-Substituted prostanoic acids

9-Oxo-15-Substituted prostanoic acids, and intermediates for their preparation are disclosed. The final products have bronchodilatory activity.

Novel 11-hydroxy-9-keto-5,6-cis-13,14-cis-prostadienoic acid derivatives

This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.

Lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates

This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.

2-Substituted-3,4-epoxycyclopentan-1-ones, and 2-substituted-3,4-epoxycyclopentan-1-ols

This disclosure describes 2-substituted-3,4-epoxy-cyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.