37835-54-4 Usage
Uses
Used in Pharmaceutical Synthesis:
1-(1-Methylpiperidin-4-yl)ethanol is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows for the creation of a wide range of therapeutic agents.
Used in Pain Management:
In the field of pain management, 1-(1-Methylpiperidin-4-yl)ethanol is used as a potent analgesic agent due to its ability to alleviate pain effectively. Its development into new analgesic drugs could potentially offer alternative treatment options for patients suffering from chronic or acute pain.
Used in Anti-Inflammatory Applications:
1-(1-Methylpiperidin-4-yl)ethanol is utilized as an anti-inflammatory agent, targeting the reduction of inflammation in various conditions. Its incorporation into pharmaceutical formulations could provide relief for individuals experiencing inflammation-related discomfort.
Used in Neurodegenerative Disease Treatment:
Within the realm of neurodegenerative disease treatment, 1-(1-Methylpiperidin-4-yl)ethanol is used as a potential therapeutic agent. Its application in this field aims to slow down or halt the progression of diseases such as Alzheimer's, Parkinson's, and multiple sclerosis.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
In the chemical industry, particularly in asymmetric synthesis, 1-(1-Methylpiperidin-4-yl)ethanol is used as a chiral auxiliary. Its role in enhancing the selectivity and yield of enantiomerically pure compounds makes it a valuable tool for creating complex molecules with specific stereochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 37835-54-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,8,3 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 37835-54:
(7*3)+(6*7)+(5*8)+(4*3)+(3*5)+(2*5)+(1*4)=144
144 % 10 = 4
So 37835-54-4 is a valid CAS Registry Number.
37835-54-4Relevant academic research and scientific papers
Synthesis, pharmacology, and molecular modeling studies of semirigid, nicotinic agonists
Waters,Spivak,Hermsmeier,Yadav,Liang,Gund
, p. 545 - 554 (2007/10/02)
Eight nicotinic agonists were synthesized, and their potencies were estimated by contracture of the frog rectus abdominis muscle. The most potent, 1-methyl-4-acetyl-1,2,3,6-tetrahydropyridine methiodide (3b), 50 times as potent as carbamylcholine, served as a template for the rest. Although all of the agonists could easily conform to the putative nicotinic pharmacophore, their potencies spanned a nearly 10,000-fold range. This pharmacophore, therefore, may be necessary but deficient. Computer-assisted molecular modeling studies helped to delineate additional factors that may contribute to potency. The factors are (1) the ground-state conformation, (2) superimposability of the hydrogen bond acceptor and the cationic head onto the template, (3) electrostatic potential at the cationic head and at the hydrogen bond acceptor site, and (4) the presence of a methyl group bonded to the carbon atom that bears the hydrogen bond acceptor. A new program, ARCHEM, was used to calculate and to visualize electrostatic potentials at the van der Waals surfaces of the agonists.
