379-53-3

Upstream product

• 462-06-6 fluorobenzene 
• 2051-90-3 Dichlorodiphenylmethane 
• 427-39-4 (4-fluorophenyl)diphenylmethanol 
• 403-33-8 methyl 4-flurobenzoate 
• 119-61-9 benzophenone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 130387-74-5 4-fluorophenylmagnesium chloride 
• 456-22-4 4-Fluorobenzoic acid 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 437-23-0 ((4-fluorophenyl)methylene)dibenzene 
• 23593-72-8 CDD₃₅₃₈ 
• 127787-66-0 dimethyl <(4-fluorophenyl)diphenylmethyl>phosphonate 
• 427-39-4 (4-fluorophenyl)diphenylmethanol 
• 1445739-96-7 C₂₀H₁₇FO 
• 41889-82-1 p-Fluorphenyldiphenylaethoxymethan 
• 1445740-00-0 C₂₂H₂₁FO 
• 1445740-02-2 C₂₃H₂₃FO 
• 1445740-03-3 C₂₆H₂₁FO 
• 1445740-05-5 C₂₂H₂₁FO 
• 289887-41-8 2-(4-fluorophenyl)-2,2-diphenylacetonitrile 
• 6060-70-4 4-fluoro-trityl 
• 464-57-3 1,2-bis-(4-fluoro-phenyl)-1,1,2,2-tetraphenyl-ethane 

Relevant academic research and scientific papers

Steric, hydrogen-bonding and structural heterogeneity effects on the nucleophilic substitution of N-(p-fluorophenyldiphenylmethyl)-4-picolinium chloride in ionic liquids

The nucleophilic substitution of N-(p-fluorophenyldiphenylmethyl)-4- picolinium chloride was investigated using water and a range of alcoholic nucleophiles in ionic liquid solvents. The reactivity patterns across the nucleophiles examined could be attributed to steric factors, which mediated the relative nucleophilicities. Reducing the hydrogen-bond acidity of the ionic liquid cation was found to generally increase the rate of reaction, however, the magnitude of this rate effect could be influenced by the steric bulk of the nucleophile and the structural heterogeneity of the ionic liquid. Preferential solvation phenomena in binary mixtures of ionic liquids were examined and suggest that the mechanism behind the hydrogen-bond solvation phenomenon arises from direct cation-mediated, rather than indirect anion-mediated, effects. The Royal Society of Chemistry 2013.

Pseudo-encapsulation-nanodomains for enhanced reactivity in ionic liquids

Domain constrained: Polar and nonpolar domains within 1-alkyl-3- methylimidazolium ionic liquids can affect reaction outcomes by pseudo-encapsulation of reactants and this has been explored for a nucleophilic substitution reaction using a cationic substrate and a range of nucleophiles. The significant rate enhancements observed correlate with the concentration of the polar reactants within the ionic liquid's polar domain. ([C nMIM]=1-alkyl-3-methylimidazolium). Copyright

Novel inhibitors of the gardos channel for the treatment of sickle cell disease

Sickle cell disease (SCD) is a hereditary condition characterized by deformation of red blood cells (RBCs). This phenomenon is due to the presence of abnormal hemoglobin that polymerizes upon deoxygenation. This effect is exacerbated when dehydrated RBCs experience a loss of both water and potassium salts. One critical pathway for the regulation of potassium efflux from RBCs is the Gardos channel, a calcium-activated potassium channel. This paper describes the synthesis and biological evaluation of a series of potent inhibitors of the Gardos channel. The goal was to identify compounds that were potent and selective inhibitors of the channel but had improved pharmacokinetic properties compared to 1, Clotrimazole. Several triarylamides such as 10 and 21 were potent inhibitors of the Gardos channel (IC50 of 10 nM) and active in a mouse model of SCD. Compound 21 (ICA-17043) was advanced into phase 3 clinical trials for SCD.

Imines as ion channel modulators

The present invention provides a class of chemical compounds useful in the treatment of sickle cell disease, diseases characterized by unwanted or abnormal cell proliferation and for the treatment of ocular disorders such as glaucoma. The active compounds

Synthesis and antifungal activity of a series of difluorotritylimidazoles

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) (15) was selected among a series of mono-, di- and trifluorotrityl-imidazole antifungal agents as the most potent fluorine containing analogue of clotrimazole.