289887-41-8

Basic information

• Product Name: 2-(4-fluorophenyl)-2,2-diphenylacetonitrile
• Synonyms: 2-(4-fluorophenyl)-2,2-diphenylacetonitrile
• CAS NO: 289887-41-8
• Molecular Weight: 287.336
• Mol File: 289887-41-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-2,2-diphenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2,2-diphenylacetonitrile(289887-41-8)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2,2-diphenylacetonitrile(289887-41-8)

Safety Data

• Hazardous Substances Data: 289887-41-8(Hazardous Substances Data)

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 86-29-3 Diphenylacetonitrile 
• 98-80-6 phenylboronic acid 
• 140-29-4 phenylacetonitrile 
• 462-06-6 fluorobenzene 
• 119-61-9 benzophenone 
• 7677-24-9 trimethylsilyl cyanide 
• 427-39-4 (4-fluorophenyl)diphenylmethanol 
• 379-53-3 p-fluorophenyldiphenylmethyl chloride 
• 544-92-3 copper(I) cyanide 

Relevant articles and documents

The Concise Synthesis of Unsymmetric Triarylacetonitriles via Pd-Catalyzed Sequential Arylation: A New Synthetic Approach to Tri- and Tetraarylmethanes

The selective synthesis of multiarylated acetonitriles via sequential palladium-catalyzed arylations of chloroacetonitrile is reported. The three aryl groups are installed via a Pd-catalyzed Suzuki-Miyaura cross coupling reaction followed by back-to-back C-H arylations to afford triarylacetonitriles in three steps with no over-arylation at any step. The triarylacetonitrile products can be converted into highly functionalized species including tetraarylmethanes. This new strategy provides rapid access to a variety of unsymmetrical tri- and tetraarylmethane derivatives from simple, readily available starting materials. (Chemical Presented)

Process development and optimization for production of a potassium ion channel blocker, ICA-17043

A scalable process for the manufacture of a potassium ion channel blocker was developed and optimized. Key features of the process include an optimized Grignard reaction, a direct cyanation of the intermediate trityl alcohol derivative, and an improved nitrile hydrolysis protocol, relative to the original acidic hydrolysis conditions, to generate the crude active pharmaceutical ingredient (API) with >95% HPLC purity. The Grignard and the cyanation reactions could be telescoped, resulting in an improved throughput compared to the original four-step process. An effective recrystallization of the API was also developed and the process scaled up to manufacture multiple batches at the pilot scale.

Imines as ion channel modulators

The present invention provides a class of chemical compounds useful in the treatment of sickle cell disease, diseases characterized by unwanted or abnormal cell proliferation and for the treatment of ocular disorders such as glaucoma. The active compounds