379-95-3

Usage

Uses

Used in Organic Synthesis:
DIMETHYL DIFLUOROMALONATE is used as a key intermediate for the synthesis of various organic compounds, contributing to the development of new materials and chemical products.
Used in Pharmaceutical Industry:
DIMETHYL DIFLUOROMALONATE is used as a building block in the development of pharmaceuticals, playing a crucial role in the creation of new drugs and therapies.
Used in Agrochemicals:
DIMETHYL DIFLUOROMALONATE is used as a starting material in the production of agrochemicals, such as pesticides and herbicides, helping to improve agricultural productivity and crop protection.
Used in Polymer Synthesis:
DIMETHYL DIFLUOROMALONATE is used as a polymerization medium for the synthesis of polymers, enabling the creation of new types of plastics, resins, and other polymeric materials.
Used in Surfactant Production:
DIMETHYL DIFLUOROMALONATE is used as a raw material in the manufacture of surfactants, which are essential components in the production of detergents, emulsifiers, and other products.
Used in Corrosion Inhibitors:
DIMETHYL DIFLUOROMALONATE is used in the production of corrosion inhibitors, helping to protect metals and other materials from degradation and wear.
Used in Plastics, Paints, and Coatings:
DIMETHYL DIFLUOROMALONATE can be copolymerized with other monomers to produce synthetic resins, which are used in the manufacturing of plastics, paints, and coatings, enhancing their properties and performance.

Precautions

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.

InChI:InChI=1/C5H6F2O4/c1-10-3(8)5(6,7)4(9)11-2/h1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 1514-85-8 2,2-difluoromalonic acid 
• 67-56-1 methanol 
• 61807-07-6 1-chloroheptafluoro-2,5-cyclohexadiene 
• 20562-79-2 methyl Pentafluorobut-3-enoate 
• 108-59-8 malonic acid dimethyl ester 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 755-73-7 methyl 3-methoxy-2,2,3,3-tetrafluoropropionate 
• 5930-67-6 difluoromalonyl difluoride 
• 69116-71-8 Methyl fluoroformyldifluoroacetate 
• 75668-21-2 1,3-bis(fluorosulfonyloxy)hexafluoropropane 

Downstream Products

• 425-99-0 Difluor-malonsaeure-diamid 

Relevant academic research and scientific papers

PROCESSES FOR MAKING SERD TRICYCLIC COMPOUNDS HAVING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY

Provided herein are processes for the preparation of compounds useful in the treatment of cancer.

Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet-Spengler Condensation

GDC-9545 is a selective estrogen receptor degrader that is being developed as a treatment for ER+/HER2- breast cancer. A robust, convergent manufacturing process for GDC-9545 was developed. The process features a Wenker aziridine synthesis to produce the key starting material tryptamine 11, a highly efficient C-N coupling between aminoazetidine 9 and 2,6-difluoro-4-bromobenzaldehyde diethyl acetal (33) to construct key intermediate 10, and a crystallization-driven diastereoselective Pictet-Spengler reaction to furnish the active pharmaceutical ingredient GDC-9545·tartrate.

Microwave-assisted rapid electrophilic fluorination of 1,3-dicarbonyl derivatives with Selectfluor

A microwave-assisted fluorination method for 1,3-dicarbonyl compounds using Selectfluor has been developed. 2-Monofluorinated products can be obtained in high yield in neutral reaction conditions with addition of 1 eq. of Selectfluor. Treatment of 1,3-dicarbonyls with 3 eq. of Selectfluor in the presence of tetrabutylammonium hydroxide (TBAH) as the base results in the formation of 2,2-difluorinated derivatives only.

Perfluoroepoxycarboxylates. Preparation and some properties

Perfluoroepoxycarboxylates were obtained by oxidation with molecular oxygen of esters of unsaturated perfluoroepoxycarboxylic acids CF2=CF(CF2)nCO2CH3 under UV irradiation. The isomeric transformations and thermal stability of the methyl pentafluoro-3,4-epoxybutanate were studied. In the reaction of the above compound with Et3N was obtained methyl tetrafluoro-3-fluoroformylpropanate, and with SbF5 on graphite arised methyl pentafluoroacetate.

Preparation of difluoromalonyl fluoride

Carboxylic ester and acyl fluoride groups are interchanged in the presence of a metal fluoride catalyst or a metal fluoride/strong sulfonic acid catalyst combination to produce fluorinated mono- and diacyl fluorides.