379253-66-4Relevant academic research and scientific papers
Iodine-Mediated Domino Oxidative Cyclization: One-Pot Synthesis of 1,3,4-Oxadiazoles via Oxidative Cleavage of C(sp2)-H or C(sp)-H Bond
Fan, Yuxing,He, Yongqin,Liu, Xingxing,Hu, Ting,Ma, Haojie,Yang, Xiaodong,Luo, Xinliang,Huang, Guosheng
, p. 6820 - 6825 (2016)
An I2-promoted, metal-free domino protocol for one-pot synthesis of 1,3,4-oxadiazoles has been developed via oxidative cleavage of C(sp2)-H or C(sp)-H bonds, followed by cyclization and deacylation. In this reaction, the use of K2CO3 as a base is found to be an essential factor in the cyclization and the C-C bond cleavage. This procedure proceeded smoothly in moderate to high yields with good functional group compatibility.
Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles via Oxidative C(CO)-C(Methyl) Bond Cleavage of Methyl Ketones
Gao, Qinghe,Liu, Shan,Wu, Xia,Zhang, Jingjing,Wu, Anxin
supporting information, p. 2960 - 2963 (2015/06/30)
A new strategy for the synthesis of 1,3,4-oxadiazoles was established through direct annulation of hydrazides with methyl ketones. It was found that the use of K2CO3 as a base achieves an unexpected and highly efficient C-C bond clea
A facile and expeditious one-pot synthesis of α-Keto-1,3,4- oxadiazoles
Kumar, Dalip,Pilania, Meenakshi,Arun,Mishra, Bhupendra
, p. 1137 - 1141 (2014/05/20)
An efficient and high-yielding protocol for the preparation of α-keto-1,3,4-oxadiazoles has been developed. Formation of α-keto-1,3,4-oxadiazoles involves the 2-iodoxybenzoic acid/ tetraethylammonium bromide mediated oxidative cyclization of hydrazide-hyd
