37988-38-8

Basic information

• Product Name: 2-PYRIDIN-2-YL-PROPAN-2-OL
• Synonyms: 1-PYRIDYL-1,1-DIMETHYLMETHANOL;2-(2-PYRIDYL)PROPAN-2-OL;2-PYRIDIN-2-YL-PROPAN-2-OL;a,a-diMethyl-2-PyridineMethanol;2-(2-Hydroxyprop-2-yl)pyridine
• CAS NO: 37988-38-8
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Mol File: 37988-38-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 49-50 °C
• Boiling Point: 226.8 °C at 760 mmHg
• Flash Point: 91 °C
• Appearance: white/crystal
• Density: 1.052 g/cm³
• Vapor Pressure: 0.0453mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.61±0.29(Predicted)
• CAS DataBase Reference: 2-PYRIDIN-2-YL-PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-2-YL-PROPAN-2-OL(37988-38-8)
• EPA Substance Registry System: 2-PYRIDIN-2-YL-PROPAN-2-OL(37988-38-8)

Safety Data

• Hazardous Substances Data: 37988-38-8(Hazardous Substances Data)

Usage

General Description

2-Pyridin-2-yl-propan-2-ol, also known as 2-(2-Pyridyl)propan-2-ol, is a chemical compound that belongs to the class of pyridine derivatives. It is an alcohol derivative with a pyridine ring attached to a propanol group. This chemical is commonly used in organic synthesis and pharmaceutical research as a building block in the production of various pharmaceutical drugs and other biologically active compounds. It exhibits both antibacterial and antifungal properties, making it a potential candidate for the development of new drugs for the treatment of infectious diseases. Additionally, it has been studied for its potential use as a chiral auxiliary in asymmetric synthesis due to its ability to induce stereo-selective reactions.

InChI:InChI=1/C8H11NO/c1-8(2,10)7-5-3-4-6-9-7/h3-6,10H,1-2H3

Upstream product

• 110-86-1 pyridine 
• 67-64-1 acetone 
• 17624-36-1 2-pyridyllithium 
• 109-04-6 2-bromo-pyridine 
• 1122-62-9 2-acetylpyridine 
• 917-54-4 methyllithium 
• 74-83-9 methyl bromide 
• 917-64-6 methyl magnesium iodide 
• 75-16-1 methylmagnesium bromide 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 2524-52-9 ethyl-2-picolinate 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 6515-13-5 2-isopropenylpyridine 
• 5944-41-2 2-tert-butylpyridine 
• 1122-62-9 2-acetylpyridine 

Relevant articles and documents

Synthesis, structure and oxo-transfer properties of dioxotungsten(VI) complexes with pyridine-based NO- and NS-bidentate ligands

Treatment of [WO2Cl2(DME)] with 2-pyridylalkoxo NO-bidentate ligands [HLn (n = 1-5)] in the presence of n-BuLi or 2-pyridylthiolato NS-bidentate ligands [LiLn (n = 6, 7)] gave the corresponding dioxotungsten(VI)

Mechanism of Oxidative Dehydrogenation of Alcohols co-ordinated to Ruthenium

The oxidative dehydrogenation of the complexes 2+, 2+ and >2+ to the corresponding carbonyl species has been studied in aqueous solution by kinetic and electrochemical techniques.The mechanistic scheme was found to involve the intermediacy of a ruthenium(IV)-alkoxide species, formed by disproportionation of the ruthenium(III) complex produced in the initial step of the oxidation process.The rate-determining removal of the proton from the α-carbon atom of the chelate ring is general-base catalysed.

Electrochemical properties and C-H bond oxidation activity of [Ru(tpy)(pyalk)Cl]+ and [Ru(tpy)(pyalk)(OH)]+

[Ru(tpy)(pyalk)Cl]Cl (pyalk = 2-(2′-pyridyl)-2-propanol) was synthesized and characterized crystallographically and electrochemically. Upon dissolution in water and acetonitrile, [Ru(tpy)(pyalk)Cl]Cl was found to form [Ru(tpy)(pyalk)Cl]+ and [Ru(tpy)(pyalk)(OH)]+, respectively. The Ru(ii/iii) couple of [Ru(tpy)(pyalk)Cl]+ was found to be relatively low compared to that of other Ru complexes in acetonitrile, but the Ru(iii/iv) couple was not significantly different than other Ru complexes bearing anionic ligands. Pourbaix diagrams were generated for [Ru(tpy)(phpy)(OH2)]+ (phpy = 2-phenylpyridine) and [Ru(tpy)(pyalk)(OH)]+ in water, and it was found that [Ru(tpy)(pyalk)(OH)]+ has a lower Ru(ii/iii) potential than [Ru(tpy)(phpy)(OH2)]+ under neutral to alkaline pH. [Ru(tpy)(pyalk)(OH)]+ was found to catalyze C-H bond hydroxylation of secondary alkanes and epoxidation of alkenes using cerium(iv) ammonium nitrate as the primary oxidant.

Ligand Tuning in Pyridine-Alkoxide Ligated Cp?IrIII Oxidation Catalysts

Six novel derivatives of pyridine-alkoxide ligated Cp?IrIII complexes, potent precursors for homogeneous water and C-H oxidation catalysts, have been synthesized, characterized, and analyzed spectroscopically and kinetically for ligand effects. Variation of alkoxide and pyridine substituents was found to affect their solution speciation, activation behavior, and oxidation kinetics. Application of these precursors to catalytic C-H oxidation of ethyl benzenesulfonate with aqueous sodium periodate showed that the ligand substitution pattern, solution pH, and solvent all have pronounced influences on initial rates and final conversion values. Correlation with O2 evolution profiles during C-H oxidation catalysis showed these competing reactions to occur sequentially, and demonstrates how it is possible to tune the activity and selectivity of the active species through the NO ligand structure.