10493-37-5

Basic information

• Product Name: 3-(2-METHOXY-PHENYL)-PROPAN-1-OL
• Synonyms: 3-(2-METHOXY-PHENYL)-PROPAN-1-OL;NSC105519;2-Methoxybenzene-1-propanol;Benzenepropanol, 2-Methoxy-;2-Methoxybenzenepropanol
• CAS NO: 10493-37-5
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.21696
• Mol File: 10493-37-5.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 271.2 °C at 760 mmHg
• Flash Point: 113.4 °C
• Appearance: /
• Density: 1.037 g/cm³
• Vapor Pressure: 0.00321mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2-METHOXY-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHOXY-PHENYL)-PROPAN-1-OL(10493-37-5)
• EPA Substance Registry System: 3-(2-METHOXY-PHENYL)-PROPAN-1-OL(10493-37-5)

Safety Data

• Hazardous Substances Data: 10493-37-5(Hazardous Substances Data)

Usage

General Description

3-(2-Methoxy-Phenyl)-Propan-1-ol is an organic compound that falls into the category of phenols, which are aromatic compounds containing a hydroxyl functional group. The chemical structure is comprised of a three carbon propan-1-ol chain, a methoxy group and a phenyl group. It is known for its soluble property in water due to the presence of hydroxyl group which is also responsible for forming hydrogen bonds. The exact physical and chemical properties such as boiling point, melting point, density, and refractive index may differ depending on the purity and the condition of the sample. Future studies could reveal more potential applications for this chemical in various industries including pharmaceutical, cosmetic, and chemical manufacturing industry. It's also worth noting the importance of safe handling and usage considering it may be harmful if swallowed or contact with skin.

InChI:InChI=1/C10H14O2/c1-12-10-7-3-2-5-9(10)6-4-8-11/h2-3,5,7,11H,4,6,8H2,1H3

Upstream product

• 55001-09-7 methyl 3-(2-methoxyphenyl)propanoate 
• 1504-74-1 2-methoxycinnamaldehyde 
• 14533-89-2 (E)-2-cyano-3-(2-methoxyphenyl)-2-propenoic acid ethyl ester 
• 529-28-2 4-iodoanisol 
• 33538-83-9 3-(2-methoxyphenyl)propanal 
• 201230-82-2 carbon monoxide 
• 612-15-7 o-methoxystyrene 
• 1011-54-7 2-methoxycinnamic acid 
• 767-91-9 1-ethynyl-2-methoxybenzene 
• 33877-05-3 ethyl 3-(2-methoxyphenyl)acrylate 
• 612-16-8 (2-methoxyphenyl)methanol 
• 1504-61-6 (E)-3-(2-methoxyphenyl)prop-2-en-1-ol 
• 1504-61-6 2-methoxycinnamyl alcohol 
• 60-29-7 diethyl ether 

Downstream Products

• 723287-10-3 3-(2-methoxyphenyl)propyl sulfamate 
• 408308-07-6 5-(2'-methoxyxyphenyl)pentanoic acid 
• 643746-88-7 5-(2-methoxyphenyl)pentanoic acid ethyl ester 
• 14374-55-1 5-(2-methoxyphenyl)pentan-1-ol 
• 60125-24-8 (E)-3-(2-methoxyphenyl)propenal 
• 33538-82-8 5-Acetyl-2-methoxyhydrozimtalkohol 
• 72734-85-1 1-(3-chloropropyl)-2-methoxybenzene 
• 13523-30-3 1-(3,5-dinitro-benzoyloxy)-3-(2-methoxy-phenyl)-propane 
• 38011-77-7 1-(3-bromopropyl)-2-methoxybenzene 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 21863-32-1 N-benzyltetrahydroquinoline 

Relevant articles and documents

Salt-Free Strategy for the Insertion of CO2 into C?H Bonds: Catalytic Hydroxymethylation of Alkynes

A copper(I) catalyst enables the insertion of carbon dioxide into alkyne C?H bonds by using a suitable organic base with which hydrogenation of the resulting carboxylate salt with regeneration of the base becomes thermodynamically feasible. In the presence of catalytic copper(I) chloride/4,7-diphenyl-1,10-phenanthroline, polymer-bound triphenylphosphine, and 2,2,6,6-tetramethylpiperidine as the base, terminal alkynes undergo carboxylation at 15 bar CO2 and room temperature. After filtration, the ammonium alkynecarboxylate can be hydrogenated to the primary alcohol and water at a rhodium/molybdenum catalyst, regenerating the amine base. This demonstrates the feasibility of a salt-free overall process, in which carbon dioxide serves as a C1 building block in a C?H functionalization.

Iridium-Catalyzed Domino Hydroformylation/Hydrogenation of Olefins to Alcohols: Synergy of Two Ligands

A novel one-pot iridium-catalyzed domino hydroxymethylation of olefins, which relies on using two different ligands at the same time, is reported. DFT computation reveals different activities for the individual hydroformylation and hydrogenation steps in the presence of mono- and bidentate ligands. Whereas bidentate ligands have higher hydrogenation activity, monodentate ligands show higher hydroformylation activity. Accordingly, a catalyst system is introduced that uses dual ligands in the whole domino process. Control experiments show that the overall selectivity is kinetically controlled. Both computation and experiment explain the function of the two optimized ligands during the domino process.

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).

Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β2-adrenergic receptor (β2AR) suggested that ligands pause at transient, less-conserved MBSs. We envisioned that MBSs can be regarded as allosteric binding sites and targeted by homobivalent bitopic ligands linking two identical pharmacophores. Such ligands were designed based on docking of the antagonist (S)-alprenolol into the OBS and an MBS and synthesized. Pharmacological characterization revealed ligands with similar potency and affinity, slightly increased β2/β1AR-selectivity, and/or substantially slower β2AR off-rates compared to (S)-alprenolol. Truncated bitopic ligands suggested the major contribution of the metastable pharmacophore to be a hydrophobic interaction with the β2AR, while the linkers alone decreased the potency of the orthosteric fragment. Altogether, the study underlines the potential of targeting MBSs for improving the pharmacological profiles of ligands.