38076-73-2Relevant articles and documents
Utilizing d–pπ Bonds for Ultralong Organic Phosphorescence
Tian, Shuai,Ma, Huili,Wang, Xuan,Lv, Anqi,Shi, Huifang,Geng, Yun,Li, Jie,Liang, Fushun,Su, Zhong-Min,An, Zhongfu,Huang, Wei
supporting information, p. 6645 - 6649 (2019/04/04)
Developing pure organic materials with ultralong lifetimes is attractive but challenging. Here we report a concise chemical approach to regulate the electronic configuration for phosphorescence enhancement. After the introduction of d–pπ bonds into a phenothiazine model system, a phosphorescence lifetime enhancement of up to 19 times was observed for DOPPMO, compared to the reference PPMO. A record phosphorescence lifetime of up to 876 ms was obtained in phosphorescent phenothiazine. Theoretical calculations and single-crystal analysis reveal that the d–pπ bond not only reduces the (n, π*) proportion of the T1 state, but also endows the rigid molecular environment with multiple intermolecular interactions, thus enabling long-lived phosphorescence. This finding makes a valuable contribution to the prolongation of phosphorescence lifetimes and the extension of the scope of phosphorescent materials.
ORGANIC LIGHTEMITTING COMPOUND HAVING PHOSPHORESCENT CHARACTERISTIC AT ROOM TEMPERATURE, AND PHOSPHORESCENT ORGANIC LIGHT EMITTING DEVICE INCLUDING THE ORGANIC LIGHTEMITTING COMPOUND
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Paragraph 0055, (2019/10/23)
Disclosed is an organic light-emitting compound having a phosphorescent characteristic at room temperature and a phosphorescent organic light-emitting device containing the same. The organic light-emitting compound includes a compound represented by a fol
Synthesis and bio-evaluation of phenothiazine derivatives as new anti-tuberculosis agents
He, Chun-Xian,Meng, Hui,Zhang, Xiang,Cui, Hua-Qing,Yin, Da-Li
supporting information, p. 951 - 954 (2015/08/18)
Abstract Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents.
Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's disease
Tin, Gary,Mohamed, Tarek,Gondora, Nyasha,Beazely, Michael A.,Rao, Praveen P. N.
, p. 1930 - 1941 (2015/11/17)
A group of tricyclic phenothiazines (6a, 6b and 7a-l) and phenoselenazines (12a, 12b and 13a-l) was designed, synthesized and evaluated as multi-targeting ligands aimed at the cholinergic, amyloid and oxidative stress pathways of Alzheimer's disease. The phenothiazine derivative 7j (2-chloro-10H-phenothiazin-10-yl-(4-methoxyphenyl)methanone) was identified as the best dual, non-selective cholinesterase inhibitor (AChE IC50 = 5.9 ± 0.6 μM; BuChE IC50 = 5.3 ± 0.5 μM), whereas in the corresponding phenoselenazine series, 13j (2-chloro-10H-phenoselenazin-10-yl-(4-methoxyphenyl)methanone) exhibited good non-selective cholinesterase inhibition (AChE IC50 = 5.8 ± 0.4 μM; BuChE IC50 = 4.9 ± 0.5 μM). Interestingly, N-10 unsubstituted phenothiazine 6a (AChE IC50 = 7.3 ± 0.6 μM; BuChE IC50 = 5.8 ± 0.5 μM; Aβ1-42 aggregation inhibition = 62%; DPPH scavenging = 92%), and the corresponding phenoselenazine bioisostere 12a (AChE IC50 = 5.6 ± 0.4 μM; BuChE IC50 = 3.0 ± 0.5 μM; Aβ1-42 aggregation inhibition = 45.6%; DPPH scavenging = 84.4%) were able to exhibit multi-targeting ability by demonstrating cholinesterase inhibition, beta-amyloid aggregation and antioxidant properties. These results show that fused tricyclic ring systems based on either phenothiazine or phenoselenazine templates can be useful to develop hybrid small molecules to target multiple pathological routes associated with Alzheimer's disease.
N-benzoylated phenoxazines and phenothiazines: Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
Prinz, Helge,Chamasmani, Behfar,Vogel, Kirsten,B?hm, Konrad J.,Aicher, Babette,Gerlach, Matthias,Günther, Eckhard G.,Amon, Peter,Ivanov, Igor,Müller, Klaus
supporting information; experimental part, p. 4247 - 4263 (2011/08/05)
A total of 53 N-benzoylated phenoxazines and phenothiazines, including their S-oxidized analogues, were synthesized and evaluated for antiproliferative activity, interaction with tubulin, and cell cycle effects. Potent inhibitors of multiple cancer cell l
Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine
Darvesh, Sultan,McDonald, Robert S.,Darvesh, Katherine V.,Mataija, Diane,Conrad, Sarah,Gomez, Geraldine,Walsh, Ryan,Martin, Earl
, p. 6367 - 6378 (2008/03/27)
Evidence suggests that specific inhibition of butyrylcholinesterase may be an appropriate focus for the development of more effective drugs to treat dementias such as Alzheimer's disease. Butyrylcholinesterase is a co-regulator of cholinergic neurotransmi
Chemoselective deoxygenation of sulfoxides with titanium tetraiodide
Shimizu,Shibuya,Hayakawa
, p. 1437 - 1438 (2007/10/03)
Chemoselective deoxygenation of sulfoxides was carried out using TiI4 as a reducing agent to give sulfides in good to excellent yields.
