38087-02-4

Usage

Uses

Used in Food Industry:
2,3-Butanedione, 1-phenylis used as a flavoring agent for its sweet, caramel-like aroma and taste, enhancing the flavor profiles of various food products.
Used in Perfumery:
In the perfume industry, 2,3-Butanedione, 1-phenylserves as a fragrance component, contributing to the creation of complex and appealing scent profiles in perfumes and other fragranced products.
Used as a Chemical Intermediate:
2,3-Butanedione, 1-phenylis utilized as a chemical intermediate in the synthesis of other compounds, playing a crucial role in the production of various chemical products.
Used in Occupational Health Research:
2,3-Butanedione, 1-phenylhas been studied for its potential role in the development of lung diseases, particularly in workers exposed to high levels of the chemical. This research is vital for understanding and mitigating the health risks associated with exposure to 2,3-Butanedione, 1-phenyl- in certain occupational settings.

Upstream product

• 5440-25-5 3-(hydroxyimino)-4-phenylbutan-2-one 
• 6362-60-3 3-hydroxy-4-phenylbut-3-en-2-one 
• 6249-79-2 1-(3-phenyloxiran-2-yl)ethanone 
• 1134-87-8 3-benzyl-pentane-2,4-dione 
• 76837-19-9 2-Benzyl-3-methoxy-2-trimethylsiloxy-3-butennitril 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 33598-22-0 1-Phenyl-3-methylprop-2-yne 
• 74817-49-5 (E)-3-(methoxyimino)-4-phenylbutan-2-one 
• 62763-33-1 (+/-)-3-hydroxy-1-phenyl-2-butanone 
• 100-39-0 benzyl bromide 
• 56583-94-9 (phenylacetyl)trimethylsilane 
• 852064-29-0 (E)-2-phenyl-1-(trimethylsilyl)vinyl benzoate 
• 852064-32-5 (Z)-3-oxo-1-phenylbut-1-en-2-yl benzoate 
• 852064-34-7 3,3-dimethoxy-1-phenylbutan-2-one 

Downstream Products

• 56530-27-9 1-phenyl-butane-2,3-dione-bis-phenylhydrazone 
• 42812-90-8 2-benzyl-3-methyl-quinoxaline 
• 76641-33-3 6-benzyl-7-methyl-8-D-ribitylpteridine-2,4(3H,8H)-dione 
• 875856-94-3 1-phenyl-butane-2,3-dione-bis thiosemicarbazone 

Relevant academic research and scientific papers

A Facile General Route to α-Keto Esters and α-Diketones

A novel synthetic route to α-keto esters and α-diketones through ozonolytic fragmentation of α-substituted acetoacetic esters and α-substituted acetylacetones is described.

[1,3]-Claisen rearrangement via removable functional group mediated radical stabilization

A thermal O-to-C [1,3]-rearrangement of α-hydroxy acid derived enol ethers was achieved under mild conditions. The 2-aminothiophenol protection of carboxylic acids facilitates formation of the [1,3] precursor and its thermal rearrangement via stabilization of a radical intermediate. Experimental and theoretical evidence for dissociative radical pair formation, its captodative stability via aminothiophenol, and a unique solvent effect are presented. The aminothiophenol was deprotected from rearrangement products as well as after derivatization to useful synthons.

Ozonolysis of Alkynes - A Flexible Route to Alpha-Diketones: Synthesis of AI-2

A mild procedure for the low-temperature conversion of alkynes to diketones has been developed and employed in the synthesis of AI-2.

Synthesis of 1,2-diketones from β-keto nitriles via a protection-oxidative-decyanation-deprotection protocol

A variety of 1,2-diketones were prepared from -keto nitriles via a three-step protocol including the protection of the ketones with methoxyamine, oxidative decyanation, and microwave-assisted deprotection in the final step. This approach provides a novel and efficient access to a wide scope of symmetric and unsymmetric 1,2-diketones using molecular oxygen as the oxidant in the decyanation process. Georg Thieme Verlag Stuttgart - New York.

Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates

Chiral oxidovanadium(V) methoxides prepared from 3,5-disubstituted-N- salicylidene-l-tert-butylglycines and vanadyl sulfate in air-saturated MeOH serve as highly enantioselective catalysts for asymmetric aerobic oxidations and kinetic resolution of alkyl, aryl, and heteroaryl α-hydroxy-ketones with differed α-substituents at ambient temperature in toluene or TBME (tert-butyl methyl ether). The best scenarios involve the use of complexes which bear the tridendate templates derived from 3,5-diphenyl- or 3-o-biphenyl-5-nitro-salicyaldehyde. The kinetic resolution selectivities of the aerobic oxidation process are in the range of 12 to >1000 based on the selectivity factors (krel).

Rhodium-catalyzed acylation of vinylsilanes with acid anhydrides

A catalytic acylation of vinylsilane with acid anhydride is accomplished by the use of [RhCl(CO)2]2, in which the transmetalation between vinylsilane and rhodium(I) carbonyl complex plays a key role. The application of this acylation reaction to (1-acyloxyvinyl)silanes provides synthetic methods for α-acyloxy enones, α-diketones, and their derivatives.

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

High-valent metalloporphyrin, Fe(tpp)OTf, catalyzed rearrangement of α,β-epoxy ketones into 1,2-diketones

Iron(III) tetraphenylporphyrin triflate, Fe(tpp)OTf, works as an efficient and characteristic Lewis acid catalyst in the selective rearrangement of α,β-epoxy ketones into 1,2-diketones.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1

Structure-reactivity dependence in the rearrangements of a family of alkylacetoxycarbenes

Absolute rate constants and activation parameters are presented for the 1,2-H and 1,2-acetyl migrations of a family of alkylacetoxycarbenes.