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(3-AMINO-4-PYRIDINYL)PHENYLMETHANONE, with the molecular formula C12H10N2O, is a chemical compound characterized by a pyridine ring connected to a phenylmethanone group via an amino group. This unique structure endows it with specific properties that make it valuable in various applications, particularly in the synthesis of pharmaceuticals and organic compounds. Its potential extends to medicine and material science, highlighting the importance of careful handling and adherence to safety protocols in laboratory settings.

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  • 3810-11-5 Structure
  • Basic information

    1. Product Name: (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE
    2. Synonyms: (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE;3-AMINO-4-BENZOYLPYRIDINE;(3-AMinopyridin-4-yl)(phenyl)Methanone
    3. CAS NO:3810-11-5
    4. Molecular Formula: C12H10N2O
    5. Molecular Weight: 198.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 3810-11-5.mol
  • Chemical Properties

    1. Melting Point: 126-128 °C
    2. Boiling Point: 423.7 °C at 760 mmHg
    3. Flash Point: 210.1 °C
    4. Appearance: /
    5. Density: 1.215 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 4.03±0.18(Predicted)
    10. CAS DataBase Reference: (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE(3810-11-5)
    12. EPA Substance Registry System: (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE(3810-11-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3810-11-5(Hazardous Substances Data)

3810-11-5 Usage

Uses

Used in Pharmaceutical Synthesis:
(3-AMINO-4-PYRIDINYL)PHENYLMETHANONE is utilized as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of diverse molecular entities with potential medicinal properties.
Used in Organic Compounds Synthesis:
In the realm of organic chemistry, (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE serves as a building block for the synthesis of a wide range of organic compounds. Its versatility in forming different chemical entities makes it a valuable asset in organic synthesis processes.
Used in Medical Research:
Due to its distinctive chemical structure, (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE may have potential applications in medical research, where it could be explored for its properties in drug discovery and development, as well as in understanding biological processes at the molecular level.
Used in Material Science:
(3-AMINO-4-PYRIDINYL)PHENYLMETHANONE's unique structure and properties also suggest potential uses in material science, where it could be employed in the development of new materials with specific characteristics, such as those with enhanced stability, reactivity, or other desirable properties.

Check Digit Verification of cas no

The CAS Registry Mumber 3810-11-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,1 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3810-11:
(6*3)+(5*8)+(4*1)+(3*0)+(2*1)+(1*1)=65
65 % 10 = 5
So 3810-11-5 is a valid CAS Registry Number.

3810-11-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3-aminopyridin-4-yl)-phenylmethanone

1.2 Other means of identification

Product number -
Other names 3-Amino-4-benzoyl-pyridin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3810-11-5 SDS

3810-11-5Relevant articles and documents

Quinolinones as Inhibitors of Translation Initiation Complex

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Paragraph 0530, (2018/03/25)

Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.

PROTEIN KINASE INHIBITORS

-

, (2015/01/09)

The present invention provides a compound incorporating a group of formula (I) wherein: 1 of X, Y and Z is nitrogen and the other 2 are carbon; V is sulpur or carbon; R3 is oxygen or fluorine; R4 is an optionally present C1-3 alkyl group optionally substituted by fluorine; R5 is an optionally present cyclic group with 5-7 heavy atoms in the ring which may be carbocyclic or heterocyclic and aromatic or aliphatic and is optionally substituted, e.g. by a halogen, C1-2 alkyl or fluoroalkyl, OH, OR6, cyano, COOR6, CONHR6, sulfonamide or NHR6, in which R6 is a C1-2 alkyl or fluoroalkyl; at least one of R4 and R5 is present and R4 and R5 may both be present; m and n are each 1 or 2 depending on the identity of V and R3; when n=2 each R3 may be the same or different but are preferably the same, when m=2, each R4 and each R5 may be the same or different but are preferably the same; and W represents hydrogen, carbon, nitrogen, oxygen or sulphur; or incorporating a salt, hydrate or solvate of a group of formula (I); as well as therapeutic uses of these compounds, in particular as inhibitors of protein kinase activity and in the treatment of inflammation, inflammatory conditions and cancer.

Synthesis of 4-aryl-1,7-naphthyridine-2(1H)-thiones by the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines Generated in situ from the corresponding Isocyanides

Kobayashi, Kazuhiro,Kozuki, Taketoshi,Suzuki, Teruhiko

experimental part, p. 556 - 563 (2012/05/20)

A convenient synthis for 4-substituted and 3,4-disubstituted 1,7-naphthyridine-2(1H)-thiones 7 has been developed. The method is based on the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines 6, generated in situ by the treatment of the respective isocyanides 5 with S 8 in the presence of a catalytic amount of selenium. The isocyanides 5 can be easily prepared from commercially available pyridin-3-amine by conventional organic reactions.

Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase

Lumeras, Wenceslao,Caturla, Francisco,Vidal, Laura,Esteve, Cristina,Balagué, Cristina,Orellana, Adelina,Domínguez, María,Roca, Ramón,Huerta, Josep M.,Godessart, Núria,Vidal, Bernat

experimental part, p. 5531 - 5545 (2010/02/28)

A novel series of aminopyridine N-oxides were designed, synthesized, and tested for their ability to inhibit p38α MAP kinase. Some of these compounds showed a significant reduction in the LPS-induced TNFR production in human whole blood. Structure-activit

Synthesis of aza analogues of the anticancer agent batracylin

Martínez-Viturro, Carlos M.,Domínguez, Domingo

, p. 4707 - 4710 (2008/03/13)

Three series of pyrido-fused pyrimido[2,1-a]isoindol-7-ones were prepared from readily available (aminopyridinyl)(aryl)methanones by reduction followed by a Mitsunobu reaction with phthalimide and acid-catalysed cyclodehydration. This approach provides a wide variety of aza analogues of the antitumour agent batracylin.

QUINOLINONE DERIVATIVES AS INHIBITORS OF C-FMS KINASE

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Page/Page column 29, (2010/02/10)

The invention is directed to compounds of Formulae I and II: (I) (II) wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.

Andres, J Ignacio,Alonso, Jose M,Fernandez, Javier,Iturrino, Laura,Martinez, Pedro,Meert, Theo F,Sipido, Victor K

, p. 3573 - 3577 (2007/10/03)

Following the program started at Johnson & Johnson Pharmaceutical Research & Development searching for 5-HT(2A/2C) antagonists, we now report on the synthesis of 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,4-c]-[2]benzazepine and 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,2-c]-[2]benzazepine. A new method for the synthesis of pyridobenzazepines is described as well. The affinities for several receptors as well as the mCPP antagonistic activity of the compounds synthesised are described.

Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a nevirapine analogue

Bakke,Riha

, p. 99 - 104 (2007/10/03)

A new method for preparing 3-amino-2-chloropyridines with a substituent (methyl, phenyl, carboxamide, methoxycarbonyl, acetyl, benzoyl and cyano) at the 4-position has been developed. An isoquinoline analogue of the reverse transcriptase inhibitor Nevirapine has been synthesized from the 4-amino-3-chloroisoquinoline.

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