38102-08-8Relevant academic research and scientific papers
Harnessing the TEMPO-Catalyzed Aerobic Oxidation for Machetti-De Sarlo Reaction toward Sustainable Synthesis of Isoxazole Libraries
Vadivelu, Murugan,Sampath, Sugirdha,Muthu, Kesavan,Karthikeyan, Kesavan,Praveen, Chandrasekar
, p. 13636 - 13645 (2019/10/17)
A practical synthesis of isoxazole/isoxazoline derivatives via Machetti-De Sarlo reaction under sustainable conditions has been accomplished. This protocol involves the use of readily available 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) to catalyze the
Synthesis of Isoxazolines and Oxazines by Electrochemical Intermolecular [2 + 1 + n] Annulation: Diazo Compounds Act as Radical Acceptors
Xiong, Mingteng,Liang, Xiao,Gao, Zhan,Lei, Aiwen,Pan, Yuanjiang
supporting information, p. 9300 - 9305 (2019/11/20)
Reported herein is an unprecedented synthesis of isoxazolines and oxazines through electrochemical intermolecular annulation of alkenes with tert-butyl nitrite, in which diazo compounds serve as radical acceptors. Notably, [2 + 1 + 2] and [2 + 1 + 3] annulations occur when styrenes and allylbenzenes are used as substrates, respectively. The latter reaction undergoes group migration to form more stable radical, manifesting radical route instead of conventional 1,3-dipolar cycloaddition occurs. Moreover, scale-up experiments suggest the potential application value of these transformations in industry.
Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH
Noel,Gembus,Levacher,Briere
, p. 1245 - 1249 (2014/03/21)
An organocatalysed and chemoselective one-pot oxa-Michael-cyclocondensation reaction of N-BocNHOH to unsaturated α-ketoesters is reported which affords an original entry to enantioenriched 3-isoxazoline carboxylate derivatives as biorelevant heterocyclic
Reactivity of the ester group attached isoxazoline, benzisoxazole, and isoxazole: A facial preparation of 3-acyl-substituted these heterocycles
Murai, Kenichi,Miyazaki, Shuji,Fujioka, Hiromichi
supporting information; experimental part, p. 3746 - 3749 (2012/10/07)
A facile preparation of 3-acyl-substituted isoxazolines, benzisoxazoles, and isoxazoles from the corresponding 3-carboxylate esters is described. The process, involving reaction of the ester derivative of 3-carboxylic acid substituted heterocycles with Gr
A Convinient Preparative Method of Nitrile Oxides by the Dehydration of Primary Nitro Compounds with Ethyl Chloroformate or Benzenesulfonyl Chloride in the Presence of Triethylamine
Shimizu, Tomio,Hayashi, Yoshiyuki,Shibafuchi, Hiroshi,Teramura, Kazuhiro
, p. 2827 - 2832 (2007/10/02)
Three nitrile oxides (MeOCOCN->O, PhCN->O, and EtCN->O) were effectively generated in situ by dehydration of the corresponding primary nitro compounds (RCH2NO2) with PhSO2Cl or ClCOOEt in the presence of triethylamine.Various cycloadducts were prepared by the reaction of them with dipolarophiles.Some advantages of these methods are described in comparison with other known methods.
A New Synthetic Method of Alkyl Carbonocyanidate N-Oxides
Shimizu, Tomio,Hayashi, Yoshiyuki,Teramura, Kazuhiro
, p. 2519 - 2522 (2007/10/02)
A thermal decomposition of dimethyl nitromalonate to bis(carbomethoxy)furoxan was observed at about 170 deg C.In the presence of dipolarophiles, an intermediate, methyl carbonocyanidate N-oxide MeOCOCN->O, could be trapped as cycloadducts in good yields b
