3813-27-2

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(Diethylamino)propanamide is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and medications. Its unique structure allows it to form essential bonds and reactions in the creation of various medicinal compounds.
Used in Organic Material Production:
In the chemical industry, 3-(Diethylamino)propanamide serves as a vital component in the production of organic materials. Its ability to participate in a range of chemical reactions makes it suitable for creating diverse organic substances with specific properties for various applications.
Used as a Catalyst in Organic Reactions:
3-(Diethylamino)propanamide is employed as a catalyst to facilitate and enhance the rate of organic reactions. Its presence can lower the activation energy required for reactions to proceed, making processes more efficient and improving overall yields.
Used as a Reagent in Research and Development:
In research and development settings, 3-(Diethylamino)propanamide is used as a reagent to support scientific investigations and experiments. Its involvement in chemical reactions can provide insights into reaction mechanisms and help in the discovery of new chemical processes or compounds.
Used in Chemical Supply:
3-(Diethylamino)propanamide is commonly found in chemical supply stores, catering to the needs of industries and research institutions. Its availability ensures that it can be readily incorporated into various chemical processes and experiments, supporting the advancement of chemical science and technology.

InChI:InChI=1/C7H16N2O/c1-3-9(4-2)6-5-7(8)10/h3-6H2,1-2H3,(H2,8,10)

Upstream product

• 109-89-7 diethylamine 
• 79-06-1 2-propenamide 
• 3840-67-3 sulfuric acid mono-(2-carbamoyl-ethyl) ester 
• 121-44-8 triethylamine 

Relevant academic research and scientific papers

Palladium-catalyzed C-N bond activation: The synthesis of β-amino acid derivatives from triethylamine and acrylates

In the palladium-catalyzed reaction of acrylates, C-N bond activation and acetalization occurred under different conditions. Described herein is a highly efficient palladium-catalyzed C-N bond activation reaction and subsequent new C-N bond formation to directly construct β-amino acids from triethylamine and acrylate esters in isolated yields of up to 95%. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Probing Carbocatalytic Activity of Carbon Nanodots for the Synthesis of Biologically Active Dihydro/Spiro/Glyco Quinazolinones and Aza-Michael Adducts

Herein, we report the fluorescent carbon dots as an effective and recyclable carbocatalyst for the generation of carbon-heteroatom bond leading to quinazolinone derivatives and aza-Michael adducts under mild reaction conditions. The results establish this nanoscale form of carbon as an alternative carbocatalyst for important acid catalyzed organic transformations. The mild surface acidity of carbon dots imparted by -COOH functionality could effectively catalyze the formation of synthetically challenging spiro/glycoquinazolinones under the present reaction conditions.

On-water magnetic NiFe2O4 nanoparticle-catalyzed Michael additions of active methylene compounds, aromatic/aliphatic amines, alcohols and thiols to conjugated alkenes

Here, we have demonstrated the Michael addition of active methylene compounds, aromatic/aliphatic amines, thiols and alcohols to conjugated alkenes using magnetic nano-NiFe2O4 as reusable catalyst in water. Nano-NiFe2O4 efficiently catalyzed the formation of C-C and C-X (X = N, S, O etc.) bond through 1,4-addition reactions.

Graphene oxide: An efficient and reusable carbocatalyst for aza-Michael addition of amines to activated alkenes

Graphene oxide was found to be a highly efficient, reusable and cost-effective organocatalyst for the aza-Michael addition of amines to activated alkenes to furnish corresponding β-amino compounds in excellent yields. The Royal Society of Chemistry 2011.

An efficient biomaterial supported bifunctional organocatalyst (ES-SO 3- C5H5NH+) for the synthesis of β-amino carbonyls

A biomaterial supported organocatalyst, readily synthesized by the reaction of chemically modified sulfonic group containing expanded corn starch with pyridine exhibited excellent catalytic activity for the synthesis of β-amino carbonyls in excellent yields via aza-Michael addition of amines to electron deficient alkenes. A remarkable enhancement in the reaction rates was observed with the prepared bifunctional organocatalyst in comparison to the either starch grafted sulfonic acid or the corresponding homogeneous pyridinium p-toluenesulfonate.

Silicon tetrachloride catalyzed aza-michael addition of amines to conjugated alkenes under solvent-free conditions

The efficient and very simple conjugate addition of aromatic and aliphatic amines to α,β-unsaturated carbonyl compounds under solvent-free conditions in the presence of catalytic amount of silicon tetrachloride is reported. The reaction of aryl and alkyl amines with different Michael acceptors gave the corresponding Michael adducts with simple catalyst and good to excellent yields. Georg Thieme Verlag Stuttgart New York.

Silica gel accelerated aza-Michael addition of amines to α,β-unsaturated amides

A novel method to synthesize β-amino amide has been developed via conjugated addition of amine to bulky α,β-unsaturated amides promoted by silica gel. The silica gel worked efficiently to accelerate the reaction and afforded the related adduct in good to excellent yield.

Significant rate acceleration of the aza-Michael reaction in water

The addition of amines to conjugated alkenes has been carried out in water at room temperature very efficiently without any catalyst. Significant rate acceleration of this reaction is observed in water compared to organic solvents.

Efficient, simple preparation of 1,3-diamine derivatives through addition of acrylamides with secondary amines

Reaction of acrylamides with secondary amines results in the formation of β-amino-propionamide through the addition reaction of N-H bond of amines across the double bond of acrylamides in the good to excellent yield. The structure of 2-methyl-3-(1-piperidinyl)-propionamide has been determined by X-ray analysis. Copyright Taylor & Francis, Inc.

Boric acid: A novel and safe catalyst for aza-Michael reactions in water

Boric acid efficiently catalyzes the conjugate addition of aliphatic amines to α,β-unsaturated compounds to produce β-amino compounds, with great alacrity and excellent yields, in water under mild conditions. Aromatic amines do not participate effectively in the reaction.