Palladium-catalyzed C-N bond activation: The synthesis of β-amino acid derivatives from triethylamine and acrylates

Article abstract of DOI:10.1002/ejoc.200700369

In the palladium-catalyzed reaction of acrylates, C-N bond activation and acetalization occurred under different conditions. Described herein is a highly efficient palladium-catalyzed C-N bond activation reaction and subsequent new C-N bond formation to directly construct β-amino acids from triethylamine and acrylate esters in isolated yields of up to 95%. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.