3815-63-2

Basic information

• Product Name: Urea, N-(4-chlorophenyl)-N'-(4-methylphenyl)-
• Synonyms: 1-(4-chlorophenyl)-3-(4-methylphenyl)urea;N-(4-chlorophenyl)-N'-(4-methylphenyl)urea
• CAS NO: 3815-63-2
• Molecular Formula: C₁₄H₁₃ClN₂O
• Molecular Weight: 260.72
• Mol File: 3815-63-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Urea, N-(4-chlorophenyl)-N'-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-(4-chlorophenyl)-N'-(4-methylphenyl)-(3815-63-2)
• EPA Substance Registry System: Urea, N-(4-chlorophenyl)-N'-(4-methylphenyl)-(3815-63-2)

Safety Data

• Hazardous Substances Data: 3815-63-2(Hazardous Substances Data)

Upstream product

• 21368-28-5 4-chlorobenzoyl azide 
• 106-49-0 p-toluidine 
• 104-12-1 p-chlorphenylisocyanate 
• 1073974-15-8 S-p-nitrophenyl N-p-chlorophenylthiocarbamate 
• 50882-28-5 phenyl N-(4-chlorophenyl)carbamate 
• 624-31-7 4-tolyl iodide 
• 106-47-8 4-chloro-aniline 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 
• 74-11-3 para-chlorobenzoic acid 
• 7647-01-0 hydrogenchloride 
• 861312-72-3 1-(4-chlorophenyl)-3-p-tolylcarbodiimide 
• 84784-24-7 3-(4-chlorophenyl)-1-(4-tolyl)-1-nitrosourea 
• 622-58-2 p-Tolylisocyanate 

Downstream Products

• 107676-77-7 C₁₄H₁₂ClN₃O₂ 
• 84784-24-7 3-(4-chlorophenyl)-1-(4-tolyl)-1-nitrosourea 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives

We report a facile, microwave-accelerated, one-pot tandem synthesis of unsymmetrical ureas via a Curtius rearrangement. In this method, one-pot microwave irradiation of commercially available (hetero)aromatic acids and amines in the presence of diphenylphosphoryl azide enabled extremely rapid (1-5 min) construction of an array of unsymmetrical ureas in good to excellent yields. We demonstrate the utility of our method in the efficient, gram-scale synthesis of key biologically active compounds targeting the cannabinoid 1 and α7 nicotinic acetylcholine receptors.

Kinetics and mechanism of the anilinolysis of S-aryl N-arylthiocarbamates in acetonitrile

The aminolysis reactions of S-aryl N-arylthiocarbamates (YC 6H4NH-C(=O)-SC6H4Z, 1) with anilines in acetonitrile are studied. The reaction rates are more influenced by the nucleophilicity of the nucleophile than the nucleofugality of the leaving group, but the change In the effective charge from reactants to the TS for formation of the tetrahedral intermediate is slightly greater in the leaving group (βz from-0.07 to -0.14) than In the nucleophile (βx = 0.04-0.12). The magnitude of the Broensted coefficients are in the range of values that are consistent for a stepwise mechanism with rate-limiting formation of the zwitterionic tetrahedral intermediate. Signs of cross-interaction constants, ρxy (>0), ρxz (>0) and ρyz (0), are all consistent with a stepwise mechanism. It Is concluded that the change of the amine from benzylamines to anilines causes a shift of the aminolysis mechanism from a concerted to a stepwise process. Copyright