382-93-4

Basic information

• Product Name: METHYL 2,3,3,3-TETRAFLUOROPROPIONATE
• Synonyms: 2,3,3,3-tetrafluoro-propionicacimethylester;Methyl tetrafluoropropionate;methyltetrafluoropropionate;Propionic acid, 2,3,3,3-tetrafluoro-, methyl ester;Methyl 2,3,3,3-tetrafluoropropionate 97%;Methyl2,3,3,3-tetrafluoropropionate97%;methyl 2,3,3,3-tetrafluoropropanoate;Methyl 2H-perfluoropropanoate 97%
• CAS NO: 382-93-4
• Molecular Formula: C₄H₄F₄O₂
• Molecular Weight: 160.07
• Mol File: 382-93-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 95°C
• Flash Point: 25
• Appearance: /
• Density: 1,353 g/cm3
• Refractive Index: 1.318
• CAS DataBase Reference: METHYL 2,3,3,3-TETRAFLUOROPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2,3,3,3-TETRAFLUOROPROPIONATE(382-93-4)
• EPA Substance Registry System: METHYL 2,3,3,3-TETRAFLUOROPROPIONATE(382-93-4)

Safety Data

• Hazard Codes: F
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 382-93-4(Hazardous Substances Data)

Usage

General Description

Methyl 2,3,3,3-tetrafluoropropionate is a chemical compound with the formula C4H5F4O2. It is a colorless liquid with a fruity ester-like odor. METHYL 2,3,3,3-TETRAFLUOROPROPIONATE is used as an intermediate in the production of various fluorinated compounds, including pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of organic compounds, particularly those containing fluorine atoms. Methyl 2,3,3,3-tetrafluoropropionate is considered to have low toxicity, but it should be handled with care and in accordance with safety regulations.

InChI:InChI=1/C4H4F4O2/c1-10-3(9)2(5)4(6,7)8/h2H,1H3

Upstream product

• 67-56-1 methanol 
• 392-63-2 N,N'-diethyl-1,2,2,2-tetrafluoropropionamide 
• 7664-93-9 sulfuric acid 
• 758-70-3 2,3,3,3-tetrafluoro-propionohydroximoyl fluoride; compound with methanol 
• 28509-44-6 2-chloro-2,3,3,3-tetrafluoro methylpropanoate 
• 392-41-6 methyl trifluoropropenoate 
• 40416-27-1 2H-tetrafluoropropionylfluorosulfate 
• 116-15-4 perfluoropropylene 
• 382-34-3 1,1,1,2,3,3-hexafluoro-3-methoxypropane 

Downstream Products

• 392-41-6 methyl trifluoropropenoate 
• 1647-57-0 2-hydroperfluoropropionamide 
• 344-14-9 dimethyl 2-fluoromalonate 
• 77778-66-6 methyl 2-fluoro-3,3,3-trimethoxypropanoate 

Relevant articles and documents

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Fluorine gas for life science syntheses: Green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.

Synthesis and use of partially fluorinated dialkyl ethers derived from hexafluoropropylene

A procedure was developed for preparing partially fluorinated dialkyl ethers by the reaction of hexafluoropropylene with aliphatic and polyfluorinated alcohols in the presence of KOH. On treatment with concentrated sulfuric acid, these ethers form alkyl esters of acids, and on treatment with KOH, alkenyl ethers.