382-93-4

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2,3,3,3-TETRAFLUOROPROPIONATE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure can enhance the lipophilicity, metabolic stability, and overall bioactivity of the resulting drugs, making it an essential component in the development of novel medications.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 2,3,3,3-TETRAFLUOROPROPIONATE serves as a crucial building block for the production of fluorinated agrochemicals. The incorporation of fluorine atoms into these compounds can improve their effectiveness, selectivity, and environmental persistence, leading to more efficient and targeted pest control solutions.
Used in Organic Synthesis:
METHYL 2,3,3,3-TETRAFLUOROPROPIONATE is utilized as a versatile building block in organic synthesis, particularly for the creation of organofluorine compounds. The introduction of fluorine atoms can significantly alter the physical, chemical, and biological properties of organic molecules, making METHYL 2,3,3,3-TETRAFLUOROPROPIONATE a valuable precursor in the synthesis of specialty chemicals, materials, and other fluorinated products.
Used in Research and Development:
METHYL 2,3,3,3-TETRAFLUOROPROPIONATE is also employed in research and development settings, where its unique properties are explored for potential applications in new areas of chemistry and material science. Its reactivity and the ability to form stable compounds make it an interesting subject for scientific investigation and innovation.

InChI:InChI=1/C4H4F4O2/c1-10-3(9)2(5)4(6,7)8/h2H,1H3

Upstream product

• 382-34-3 1,1,1,2,3,3-hexafluoro-3-methoxypropane 
• 67-56-1 methanol 
• 116-15-4 perfluoropropylene 
• 40416-27-1 2H-tetrafluoropropionylfluorosulfate 
• 392-41-6 methyl trifluoropropenoate 
• 28509-44-6 2-chloro-2,3,3,3-tetrafluoro methylpropanoate 
• 7664-93-9 sulfuric acid 
• 758-70-3 2,3,3,3-tetrafluoro-propionohydroximoyl fluoride; compound with methanol 
• 392-63-2 N,N'-diethyl-1,2,2,2-tetrafluoropropionamide 

Downstream Products

• 392-41-6 methyl trifluoropropenoate 
• 1647-57-0 2-hydroperfluoropropionamide 
• 77778-66-6 methyl 2-fluoro-3,3,3-trimethoxypropanoate 
• 344-14-9 dimethyl 2-fluoromalonate 

Relevant academic research and scientific papers

Synthesis method of 2,3,3,3-tetrafluoropropionate

The invention belongs to the technical field of organic chemistry and provides a synthesis method of 2,3,3,3-tetrafluoropropionate. According to the synthesis method, a N,N-disubstituted-2,3,3,3-tetrafluoropropionamide pure product or a mixture containing 0.1 percent to 99.99 percent of the N,N-disubstituted-2,3,3,3-tetrafluoropropionamide is used as a starting raw material, and is hydrolyzed and treated by an esterification one-pot method in the presence of acid or alkali and corresponding alcohol to obtain the 2,3,3,3-tetrafluoropropionate. The 2,3,3,3-tetrafluoropropionate (II) is synthesized through adopting the simple and easy-to-operate one-pot method; an applicable range is wide and conditions are moderate; the synthesis method is suitable for industrial production.

Fluorine gas for life science syntheses: Green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.

METHOD FOR PRODUCING FLUORINE-CONTAINING CARBOXYLIC ACID ESTER

[Task] It is to provide a production method that the target fluorine-containing carboxylic acid ester can be obtained from a fluorine-containing ether by a one-step reaction, that a complicated step and a troublesome operation are not necessary, and that an excessive energy is not consumed. [Solving Means] A fluorine-containing carboxylic acid ester represented by the general formula R1HCFCOOR2 is produced by reacting a fluorine-containing ether represented by the general formula R1HCFCF2OR2 (R1 represents either of a fluorine atom and a C1-4 perfluoroalkyl group, and R2 represents a monovalent organic group) with water in the presence of a solid catalyst.

Synthesis and use of partially fluorinated dialkyl ethers derived from hexafluoropropylene

A procedure was developed for preparing partially fluorinated dialkyl ethers by the reaction of hexafluoropropylene with aliphatic and polyfluorinated alcohols in the presence of KOH. On treatment with concentrated sulfuric acid, these ethers form alkyl esters of acids, and on treatment with KOH, alkenyl ethers.

SELECTIVE PHOTOCHEMICAL REDUCTION OF CARBON-CHLORINE BOND IN FLUOROPROPANOATES AND ITS QUANTUM YIELDS

Ultraviolet light initiated reduction of methyl 2,2,3-trichlorodifluoropropanoate (I), methyl 2,3-dichlorotrifluoropropanoate (II) and methyl 2-chlorotetrafluoropropanoate (III) in 2-propanol afforded methyl 2,3-dichloro-3,3-difluoropropanoate (IV), methyl 3-chloro-2,3,3-trifluoropropanoate (V) and methyl 2,3,3,3-tetrafluoropropanoate (VI) in the respective yields 81percent, 86percent and 75percent.Maximum quantum yields, Φmax, of the reduction at 254 nm for the ester IV, V and VI are 225, 240 and 270, respectively, indicating thus a chain reduction mechanism.

FACILE SYNTHESIS OF DIALKYL FLUOROMALONATES AND THEIR DERIVATIVES

Dimethyl and diethyl fluoromalonates were prepared by the stepwise basic alcoholysis of hexafluoropropene in a total yield of 50 - 55 percent.These dialkyl fluoromalonates were alkylated with alkyl halides, and the resulting dialkyl α-fluoroalkylmalonates were cyclized with urea affording 5-fluorobarbituric acid derivatives.

IONIC DIMERISATION OF METHYL TRIFLUOROPROPENOATE

Dimerisation of methyl trifluoropropenoate (I) in solvents in the presence of potassium fluoride affords stereoisomeric dimethyl perfluoro-(4-methyl-2-pentene)dioates (III), the ratio of which depends on the reaction conditions.The reaction is accompanied by formation of methyl 2,3,3,3-tetrafluoropropenoate (IV), arising by proton transfer from the solvent to the carbanionic intermediate.Under suitable conditions complete conversion of the propenoate can be achieved and he dimer is obtained in 80-90percent yield.Principal steps of the dimerisation were proved and the formation of configuration isomers is discussed in terms of kinetically controlled reaction.