77778-66-6Relevant academic research and scientific papers
SYNTHESIS OF MONOFLUORINE-SUBSTITUTED COMPOUNDS FROM SUBSTANCES CONTAINING A 1,2,2,2-TETRAFLUOROETHYL GROUP
Bogolyubskii, A. V.,Skrynnikova, A. A.,Il'chenko, A. Ya.,Popov, V. I.,Yagupol'skii, L. M.
, p. 977 - 981 (2007/10/02)
During the action of a methanol solution of sodium methoxide on compounds containing a 1,2,2,2-tetrafluoroethyl group, the latter is converted into a 2,2,2-trimethoxy-1-fluoroethyl group.This reaction was used in the synthesis of 2-fluoromethylquinoline a
REACTION OF CHLORODIFLUOROPROPENOATES WITH POTASSIUM FLUORIDE
Svoboda, Jiri,Paleta, Oldrich,Dedek, Vaclav
, p. 1272 - 1279 (2007/10/02)
Reaction of methyl 3-chlorodifluoropropenoate (I) with potassium fluoride afforded methyl trifluoropropenoate (II) which was dimerized to dimethyl perfluoro-4-methyl-2-pentenedioate (III).The reaction rate of I was not affected by the presence of the monomer II.Methyl 2-chlorodifluoropropenoate (VII) on treatment with potassium fluoride underwent dimerization and the unstable dimer X was transformed at -20 deg C into methyl 2-chloro-3,5,5-trifluoro-4-methoxycarbonyl-2,4-pentadienoate (XIII) and dimethyl 2-chloro-3-fluoro-4-trifluoromethyl-2-pentenedioate (XIV).These reactions involve a transfer of chlorine atom from the dimer X to the primarily formed 1-chloro-3,3,3-trifluoro-1-methoxycarbonylethanide (VIIa) which is transformed by this carbanion interconversion into methyl 2,2-dichlorotrifluoropropanoate (XI).The propenoate VII adds methanol in the presence of potassium fluoride whereas the propenoate I does not react under these conditions.
