38204-31-8

Upstream product

• 75-15-0 carbon disulfide 
• 3926-62-3 sodium monochloroacetic acid 
• 699-19-4 4-methoxyphenylmagnesium chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 79-11-8 chloroacetic acid 
• 2168-77-6 p-(methoxy)dithiobenzoic acid 
• 129841-40-3 ethyl 2-((4-methoxyphenylcarbonothioyl)thio)acetate 
• 58547-63-0 4-Methoxy-S-carboxymethyl-thiobenzoesaeure-piperidinium 

Downstream Products

• 27249-68-9 propyl 4-methoxybenzodithioate 
• 27249-69-0 allyl 4-methoxydithiobenzoate 
• 97617-57-7 4-Methoxy-thiobenzoesaeure-(N²,N²-dibutyl-hydrazid) 
• 37957-99-6 5-(4-methoxyphenyl)-4-[(4-methylphenyl)sulfonyl]thiazole 
• 17650-20-3 4-methoxy-thiobenzhydroxamic acid 
• 62625-55-2 4-methoxy-thiobenzoic acid hydrazide 
• 67688-19-1 5-(4-methoxy-phenyl)-[1,2,3,4]thiatriazole 
• 94216-97-4 4-Methoxy-thiobenzoesaeure-(N²,N²-dimethyl-hydrazid) 
• 35222-98-1 N¹-(4-methoxythiobenzoyl)-N²-phenylhydrazine 
• 35223-01-9 4-methoxy-thiobenzoic acid N'-(4-nitro-phenyl)-hydrazide 
• 35222-99-2 4-methoxy-thiobenzoic acid N'-p-tolyl-hydrazide 
• 52883-08-6 4-methoxy-thiobenzoic acid N'-(4-bromo-phenyl)-hydrazide 
• 35223-00-8 4-methoxy-thiobenzoic acid N'-(4-methoxy-phenyl)-hydrazide 
• 942-85-8 ethyl 4-methoxybezenecarbodithioate 

Relevant academic research and scientific papers

CONTINUOUS FLOW SYNTHESIS OF DITHIOESTER COMPOUNDS

The present technology relates to methods of producing various dithioester-containing compounds via continuous flow reactors.

Bioactivity of novel transition metal complexes of N′-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide

Cu(II), Fe(III), and Mn(II) complexes of a novel ligand N′-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide (H2mtbh) have been synthesized and characterized by elemental analyses, IR, UV-vis, NMR, mass, EPR and Moessbauer spectroscopy. The results suggest a square planar structure for [Cu(Hmtbh)Cl] and [Cu(mtbh)] whereas an octahedral structure for [Mn(Hmtbh)2] and [Fe(Hmtbh)(mtbh)]. Mn(II) and Fe(III) complexes were found to inhibit proliferation of HT29 cells. [Mn(Hmtbh)2] and [Fe(Hmtbh)(mtbh)] inhibited proliferation of HT29 cells with half maximal inhibition (IC50) of 8.15 ± 0.87 and 68.1 ± 4.8 μM, respectively, whereas H2mtbh showed growth inhibition with IC50 of 90.9 ± 7.8 μM and were able to inhibit NMT activity in vitro. Mn(II) and Fe(III) complexes inhibited NMT activity in a dose dependent manner with IC50 values of 20 ± 2.2 and 60 ± 7.2 μM, respectively, whereas ligand (H2mtbh) displayed IC50 of 3.2 ± 0.5 mM.

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2)

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. Selected compounds 23, 33-35 show sub-micromolar ADAMTS-5 potency and strong SAR trends with selectivity over the related metalloproteases ADAMTS-4 (Aggrecanase-1), MMP12, and MMP13. This series of compounds represents progress toward a selective ADAMTS-5 inhibitor as a disease modifying osteoarthritis drug.