38256-48-3Relevant academic research and scientific papers
Facile synthesis of multisubstituted benzo[b]furans via 2,3-disubstituted 6,7-furanobenzynes generated from ortho-iodoaryl triflate-type precursors
Morita, Takamoto,Nishiyama, Yoshitake,Yoshida, Suguru,Hosoya, Takamitsu
, p. 118 - 121 (2017)
2,3-Disubstituted 6,7-furanobenzynes were efficiently generated from ortho-iodoaryl triflate-type precursors using a silylmethyl Grignard reagent as the activator. The reactions between 6,7-furanobenzynes and unsymmetrical arynophiles proceeded in a highly regioselective manner. Since a variety of precursors were easily synthesizable from readily available 2,3-disubstituted 6-hydroxybenzofurans, this method enabled facile synthesis of a wide range of multisubstituted benzofurans, including π-extended molecules.
Condensations of benzil with phenols and aryl ethers mediated by tin(IV) chloride pentahydrate
Morrison, Brian J,Musgrave, Oliver C
, p. 4255 - 4260 (2007/10/03)
The reaction of benzil with phenol at 180°C in the presence of SnCl4·5H2O produces a benzofuran, a benzofuranol, a benzodifuran, and a benzofuranone. Anhydrous tin(IV) chloride also gives a benzofuranofuranone. Other phenols and their methyl ethers yield related products. The good yields of the benzo- and naphtho-furanones make the method an attractive alternative to the benzilic acid route to such compounds.
Synthesis of 2,3-diphenyl-5-methyl-6-aroylbenzo[ 1,2-b:5,4-b′]difurans under PTC conditions and their anti-microbial activity
Thirupathi Reddy,Narsimha Reddy,Kanakalingeswara Rao,Rajitha,Reddy,Sridevi
, p. 479 - 483 (2007/10/03)
2,3-Diphenyl-6-hydroxybenzofuran 1 and 2,3-diphenyl-5-acetyl-6-hydroxybenzofuran 3 have been synthesized under microwave irradiation. 2,3-Diphenyl-5-acetyl-6-aroylbenzo[1,2-b:5,4-b′]difurans 5a-h and 6a-e have been synthesized from the reaction of 3 and p
α-Heterosubstituted Phosphonate Carbanions. 11. Benzoins via an Acyl Anion Equivalent. Novel One-Pot Preparation of Benzofurans via Benzoins Using Hydriodic Acid
Koenigkramer, Rusty E.,Zimmer, Hans
, p. 3994 - 3998 (2007/10/02)
Diethyl 1-(trimethylsiloxy)-1-phenylmethanephosphonate carbanion 2 is introduced as a novel acyl anion equivalent.When 2 reacts with aldehydes or ketones, a 1,4 oxygen-oxygen silicon migration with subsequent loss of diethyl lithium phosphite is observed.An efficient method utilizing 2 for the preparation of otherwise difficultly obtainable substituted benzoins is presented.Also a novel one-pot method which offers a facile entry into the 2-phenylbenzofuran ring system from 2 via benzoin intermediates using hydriodic acid was developed.
