383-10-8

Basic information

• Product Name: 1-Methyl-4-[(trifluoromethyl)sulfonyl]benzene
• Synonyms: (Trifluoromethyl)(4-methylphenyl) sulfone;1-Methyl-4-[(trifluoromethyl)sulfonyl]benzene
• CAS NO: 383-10-8
• Molecular Formula: C₈H₇F₃O₂S
• Molecular Weight: 224.2001896
• Mol File: 383-10-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-4-[(trifluoromethyl)sulfonyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-[(trifluoromethyl)sulfonyl]benzene(383-10-8)
• EPA Substance Registry System: 1-Methyl-4-[(trifluoromethyl)sulfonyl]benzene(383-10-8)

Safety Data

• Hazardous Substances Data: 383-10-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 1151, 1990 DOI: 10.1055/s-1990-27121

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1961266-44-3 2,8-difluoro-5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 2926-29-6 Langlois reagent 
• 262373-15-9 4-methyl-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1204518-02-4 4-methylphenyl(2,4,6-trimethylphenyl)iodonium triflate 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 887144-94-7 Togni's reagent II 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 108-88-3 toluene 
• 536-57-2 p-toluene sulfinic acid 
• 2314-97-8 iodotrifluoromethane 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 1933-61-5 <4-Carboxy-3-nitro-phenyl>-trifluormethyl-sulfon 
• 194222-98-5 p-trifluoromethanesulfonylbenzyltriflone 
• 118089-89-7 1-(bromomethyl)-4-(trifluoromethylsulfonyl)benzene 
• 2192-27-0 (3-Nitro-4-methyl-phenyl)-trifluormethyl-sulfon 

Relevant articles and documents

Nucleophilic trifluoromethylation of organic substrates using (trifluoromethyl)trimethylsilane in the presence of a fluoride anion. II. A convenient route to aryltrifluoromethyl-sulfides, - sulfoxides and -sulfones

Aryltrifluoromethyl-sulfides, -sulfoxides and -sulfones can be prepared by trifluoromethylation of the corresponding arylsulfenyl, -sulfinyl and -sulfonyl halides using (trifluoromethyl)trimethylsilane in the presence of fluoride sources, such as TASF . - Keywords: Nucleophilic trifluoromethylation; (Trifluoromethyl)trimethylsilane; Fluoride anion; Aryltrifluoromethylsulfides; Aryltrifluoromethylsulfoxides; Aryltrifluoromethylsulfones

Practical and efficient synthesis of aryl trifluoromethyl sulfones from arylsulfonyl chlorides with Umemoto's reagent II

A practical and efficient method for the synthesis of aryl trifluoromethyl sulfones has been developed by a tandem reaction of arylsulfonyl chlorides with Umemoto's reagent II. The advantageous features of this method are simple operation, mild reaction conditions, wide scope of substrates, high yield of products, and easy scalability.

Copper-Mediated Di- and Monofluoromethanesulfonylation of Arenediazonium Tetrafluoroborates: Probing the Fluorine Effect

A copper-mediated di- and monofluoromethanesulfonylation of arenediazonium tetrafluoroborates using di- and monofluoromethanesulfinate reagents provides aryl difluoromethyl (or monofluoromethyl) sulfones in good yields. It was found that the relative reactivity of these sodium fluoroalkanesulfinates in the present reactions decreases in the following order: CH2FSO2Na > CF2HSO2Na > CF3SO2Na.