383-72-2

Usage

Uses

Used in Pharmaceutical Industry:
(Trifluoroacetylamino)acetic acid methyl ester is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (Trifluoroacetylamino)acetic acid methyl ester is utilized as a starting material for the creation of novel compounds with pesticidal, herbicidal, or other agricultural applications, enhancing crop protection and yield.
Used in Chemical Research:
(Trifluoroacetylamino)acetic acid methyl ester serves as a reagent in the preparation of complex organic molecules, facilitating advancements in chemical research and the discovery of new chemical entities.
Used in Biochemical Studies:
Due to its versatile chemical structure, (Trifluoroacetylamino)acetic acid methyl ester may also find applications in biochemical studies, potentially aiding in the understanding of biological processes and the development of targeted therapies.

InChI:InChI=1/C5H6F3NO3/c1-12-3(10)2-9-4(11)5(6,7)8/h2H2,1H3,(H,9,11)

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 616-34-2 methoxycarbonylmethylamine 
• 67-56-1 methanol 
• 6000-43-7 2-aminoethanoic acid hydrochloride 
• 354-38-1 2,2,2-trifluoroacetamide 
• 96-32-2 bromoacetic acid methyl ester 
• 1613110-97-6 lipodiscamide B 
• 407-25-0 trifluoroacetic anhydride 
• 1613110-96-5 lipodiscamide A 
• 56-40-6 glycine 

Downstream Products

• 107940-27-2 N-(Trifluoracetyl)-N-(trimethylsilyl)glycin-methylester 
• 60456-20-4 (E)-methyl 3-methoxy-3-phenylprop-2-enoate 
• 40203-51-8 (Z)-methyl 3-methoxy-3-phenylprop-2-enoate 
• 4525-28-4 methyl (E)-3-methoxybut-2-enoate 

Relevant academic research and scientific papers

Single Electron Transfer-Induced Selective α-Oxygenation of Glycine Derivatives

Modification of amino acids is an important strategy in organic and bioorganic chemistry. In contrast to common side-chain functionalization, backbone modification is much less explored. Especially glycine units seem to be attractive and versatile since a wide range of functionality can be potentially introduced. We report here oxidative modification of glycinates that are stable and enable further functionalization. Selective glycinate enolate oxidation by TEMPO or a FeCp2PF6/TEMPO reagent combination provides stable alkoxyamines in good to excellent yields. The methodology is expanded to glycine-containing dipeptides demonstrating selective oxygenation at the glycine unit. The orthogonal reactivity potential of oxygenated glycines for transformation to other amino acid derivatives is explored.

BF3·OEt2-TFAA Mediated Tetra-Functionalization of Amino Acids-Synthesis of Di-and Tri-Substituted 2-Trifluoromethyl Oxazoles in One Pot

A highly efficient, TFAA-BF3·OEt2 mediated multicomponent coupling of amino acid, TFAA, and aromatics provides a broad library of 2-Trifluoromethyl equipped 2,5-disubstituted/2,4,5-Trisubstituted oxazoles or N-(trifluoroacetyl)-β-Aminoalkyl ketones. This amino acid tetra-functionalization approach involves amidation (C-N), anhydride (C-O), Friedel-Crafts acylation (C-C), and Robinson-Gabriel annulation (C-O) followed by dehydrative aromatization. This reaction takes place under operationally simple, mild, and metal-free conditions using readily available amino acids and aromatic compounds.

Lipodiscamides A-C, new cytotoxic lipopeptides from discodermia kiiensis

Lipodiscamides A-C, three new lipodepsipeptides, were characterized from the marine sponge Discodermia kiiensis. These structurally rare cyclic lipodepsipeptides were found to possess an unprecedented dilactone macrocycle and, thus, represent a new family of lipopeptides. They are the only lipopeptides bearing 4S-hydroxy-trans-2-enoate, and noncanonical amino acids, l-3-ureidoalanine (Uda), E-dehydronorvaline (Denor), and d-citrulline (Cit). MTT assays against P388 and HeLa cells revealed the moderate cytotoxicity of all three compounds.